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Genomic regions underlying positive selection in local, Alpine cattle breeds
ID
Signer-Hasler, Heidi
(
Avtor
),
ID
Casanova, Lucas
(
Avtor
),
ID
Barenco, Alex
(
Avtor
),
ID
Maître, Blaise
(
Avtor
),
ID
Bagnato, Alessandro
(
Avtor
),
ID
Vevey, Mario
(
Avtor
),
ID
Berger, Beate
(
Avtor
),
ID
Simčič, Mojca
(
Avtor
),
ID
Boichon, Denis
(
Avtor
),
ID
Capitan, Aurélien
(
Avtor
),
ID
Medjugorac, Ivica
(
Avtor
),
ID
Bennewitz, Jörn
(
Avtor
),
ID
Mészáros, Gábor
(
Avtor
),
ID
Sölkner, Johann
(
Avtor
),
ID
Drögemüller, Cord
(
Avtor
),
ID
Flury, Christine
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(3,21 MB)
MD5: 12B27A96397339E114D51E74EA379CA4
URL - Izvorni URL, za dostop obiščite
https://onlinelibrary.wiley.com/doi/10.1111/age.13295
Galerija slik
Izvleček
We used genome-wide SNP data from 18 local cattle breeds from six countries of the Alpine region to characterize population structure and identify genomic regions underlying positive selection. The geographically close breeds Evolèner, Eringer, Valdostana Pezzata Nera, and Valdostana Castana were found to differ from all other Alpine breeds. In addition, three breeds, Simmental, and Original Braunvieh from Switzerland and Pinzgauer from Austria built three separate clusters. Of the 18 breeds studied, the intra-alpine Swiss breed Evolèner had the highest average inbreeding based on runs of homozygosity (FROH) and the highest average genomic relationship within the breed. In contrast, Slovenian Cika cattle had the lowest average genomic inbreeding and the lowest average genomic relationship within the breed. We found selection signatures on chromosome 6 near known genes such as KIT and LCORL explaining variation in coat color and body size in cattle. The most prominent selection signatures were similar regardless of marker density and the breeds in the data set. In addition, using available high-density SNP data from 14 of the breeds we identified 47 genome regions as ROH islands. The proportion of homozygous animals was higher in all studied animals of local breeds than in Holstein and Brown Swiss cattle, the two most important commercial breeds in the Alpine region. We report ROH islands near genes related to thermoregulation, coat color, production, and stature. The results of this study serve as a basis for the search for causal variants underlying adaptation to the alpine environment and other specific characteristics selected during the evolution of local Alpine cattle breeds.
Jezik:
Angleški jezik
Ključne besede:
diversity
,
selection signature
,
runs of homozygosity
,
cattle
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
Str. 239-253
Številčenje:
Vol. 54, iss. 3, art. 13295
PID:
20.500.12556/RUL-146996
UDK:
636.2:575
ISSN pri članku:
1365-2052
DOI:
10.1111/age.13295
COBISS.SI-ID:
141111043
Datum objave v RUL:
19.06.2023
Število ogledov:
1106
Število prenosov:
49
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Animal genetics
Skrajšan naslov:
Anim. genet.
Založnik:
Wiley
ISSN:
1365-2052
COBISS.SI-ID:
2344072
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
govedo
,
lokalne pasme
,
Alpe
,
genetika
,
genomika
Projekti
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
The Swiss Federal Office of Agriculture (FOAG)
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