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Inactivation of the enveloped virus phi6 with hydrodynamic cavitation
ID
Zupanc, Mojca
(
Author
),
ID
Zevnik, Jure
(
Author
),
ID
Filipić, Arijana
(
Author
),
ID
Gutiérrez-Aguirre, Ion
(
Author
),
ID
Ješelnik, Meta
(
Author
),
ID
Košir, Tamara
(
Author
),
ID
Ortar, Jernej
(
Author
),
ID
Dular, Matevž
(
Author
),
ID
Petkovšek, Martin
(
Author
)
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https://www.sciencedirect.com/science/article/pii/S1350417723001128
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Abstract
The COVID-19 pandemic reminded us that we need better contingency plans to prevent the spread of infectious agents and the occurrence of epidemics or pandemics. Although the transmissibility of SARS-CoV-2 in water has not been confirmed, there are studies that have reported on the presence of infectious coronaviruses in water and wastewater samples. Since standard water treatments are not designed to eliminate viruses, it is of utmost importance to explore advanced treatment processes that can improve water treatment and help inactivate viruses when needed. This is the first study to investigate the effects of hydrodynamic cavitation on the inactivation of bacteriophage phi6, an enveloped virus used as a SARS-CoV-2 surrogate in many studies. In two series of experiments with increasing and constant sample temperature, virus reduction of up to 6.3 logs was achieved. Inactivation of phi6 at temperatures of 10 and 20 °C occurs predominantly by the mechanical effect of cavitation and results in a reduction of up to 4.5 logs. At 30 °C, the reduction increases to up to 6 logs, where the temperature-induced increased susceptibility of the viral lipid envelope makes the virus more prone to inactivation. Furthermore, the control experiments without cavitation showed that the increased temperature alone is not sufficient to cause inactivation, but that additional mechanical stress is still required. The RNA degradation results confirmed that virus inactivation was due to the disrupted lipid bilayer and not to RNA damage. Hydrodynamic cavitation, therefore, has the potential to inactivate current and potentially emerging enveloped pathogenic viruses in water at lower, environmentally relevant temperatures.
Language:
English
Keywords:
enveloped viruses
,
phi6
,
SARS-CoV-2
,
virus inactivation
,
hydrodynamic cavitation
,
water decontamination
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FS - Faculty of Mechanical Engineering
Publication status:
Published
Publication version:
Version of Record
Year:
2023
Number of pages:
8 str.
Numbering:
Vol. 95, art. 106400
PID:
20.500.12556/RUL-145264
UDC:
532.528:578
ISSN on article:
1350-4177
DOI:
10.1016/j.ultsonch.2023.106400
COBISS.SI-ID:
148619523
Publication date in RUL:
14.04.2023
Views:
666
Downloads:
125
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Record is a part of a journal
Title:
Ultrasonics Sonochemistry
Shortened title:
Ultrason. sonochem.
Publisher:
Butterworth-Heinemann, Elsevier Science
ISSN:
1350-4177
COBISS.SI-ID:
707668
Licences
License:
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Secondary language
Language:
Slovenian
Keywords:
virusi z ovojnico
,
phi6
,
SARS-CoV-2
,
inaktivacija virusov
,
hidrodinamična kavitacija
,
dekontaminacija vode
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P4-0407
Name:
Okoljska in aplikativna virologija: virusi, prijatelji in sovražniki
Funder:
ARRS - Slovenian Research Agency
Project number:
P2-0401
Name:
Energetsko strojništvo
Funder:
ARRS - Slovenian Research Agency
Project number:
P2-0422
Name:
Funkcionalne tekočine za napredne energetske sisteme
Funder:
ARRS - Slovenian Research Agency
Project number:
L4-9325
Name:
Razvoj novih, okolju prijaznih, pristopov za inaktivacijo rastlinskih in humanih virusov v vodah
Funder:
ARRS - Slovenian Research Agency
Project number:
J7-1814
Name:
Kavitacija - rešitev za problematiko mikroplastike?
Funder:
ARRS - Slovenian Research Agency
Project number:
J2-3044
Name:
Kontroliranje ekstremnih kavitacijskih pogojev z lasersko funkcionalizacijo površin (eCATS)
Funder:
ARRS - Slovenian Research Agency
Project number:
J2-4480
Name:
Odstranjevanje izbranih protimikrobnih učinkovin s hibridno kavitacijsko-plazemsko tehnologijo iz vodnih matric različnih kompleksnosti (Causma)
Funder:
Other - Other funder or multiple funders
Funding programme:
Ministry of Agriculture, Forestry and Food
Funder:
Other - Other funder or multiple funders
Funding programme:
Domžale-Kamnik Wastewater Treatment Plant
Funder:
EC - European Commission
Funding programme:
H2020
Project number:
771567
Name:
An investigation of the mechanisms at the interaction between cavitation bubbles and contaminants
Acronym:
CABUM
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