Alcohol‐induced oxidative stress and the role of antioxidants in alcohol use disorder : a systematic review

Tsermpini, Evangelia Eirini (author), Plemenitaš Ilješ, Anja (author), Dolžan, Vita (author)

Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not fully elucidated. However, ethanol metabolism has been associated with increased oxidative stress through alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase metabolic pathways. We searched the PubMed and genome-wide association studies (GWAS) catalog databases to review the literature systematically and summarized the findings focusing on AUD and alcohol abstinence in relation to oxidative stress. In addition, we reviewed the ClinicalTrials.gov resource of the US National Library of Medicine to identify all ongoing and completed clinical trials that include therapeutic interventions based on antioxidants. The retrieved clinical and preclinical studies show that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.

• Language: English
• Keywords: alcohol use disorder, alcohol dependence, oxidative stress, alcohol addiction, alcohol dehydrogenase, aldehyde dehydrogenase, catalase, glutathione
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 33 str.
• Numbering: Vol. 11, iss. 7, art. 1374
• PID: 20.500.12556/RUL-145246
• UDC: 613.8
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox11071374
• COBISS.SI-ID: 115800579
• Publication date in RUL: 13.04.2023

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: motnja uživanja alkohola, odvisnost od alkohola, oksidativni stres

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0170
• Name: Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku