20.500.12556/RUL-145246 Alcohol‐induced oxidative stress and the role of antioxidants in alcohol use disorder a systematic review Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not fully elucidated. However, ethanol metabolism has been associated with increased oxidative stress through alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase metabolic pathways. We searched the PubMed and genome-wide association studies (GWAS) catalog databases to review the literature systematically and summarized the findings focusing on AUD and alcohol abstinence in relation to oxidative stress. In addition, we reviewed the ClinicalTrials.gov resource of the US National Library of Medicine to identify all ongoing and completed clinical trials that include therapeutic interventions based on antioxidants. The retrieved clinical and preclinical studies show that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration. alcohol use disorder alcohol dependence oxidative stress alcohol addiction alcohol dehydrogenase aldehyde dehydrogenase catalase glutathione motnja uživanja alkohola odvisnost od alkohola oksidativni stres true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-13 15:15:41 2023-04-13 15:15:44 2023-04-14 03:50:00 0000-00-00 00:00:00 2022 0 0 33 str. iss. 7, art. 1374 Vol. 11 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 613.8 2076-3921 10.3390/antiox11071374 115800579 RAZ_Tsermpini_Evangelia_Eirini_2022.pdf RAZ_Tsermpini_Evangelia_Eirini_2022.pdf 1 697C6483CDCD96EE57C6ED0755CE7488 0fb3f250003ee37202fc04665468d3afa207cf495b087e42372d9f4f9f69404b 26055aeb-d9fd-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167980 https://www.mdpi.com/2076-3921/11/7/1374 0 90d45f68-d9fd-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167981 Medicinska fakulteta 0 0 0