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Relationship between excreted uremic toxins and degree of disorder of children with ASD
ID
Osredkar, Joško
(
Avtor
),
ID
Žvar Baškovič, Barbara
(
Avtor
),
ID
Finderle, Petra
(
Avtor
),
ID
Bobrowska-Korczak, Barbara
(
Avtor
),
ID
Gątarek, Paulina
(
Avtor
),
ID
Rosiak, Angelina
(
Avtor
),
ID
Giebułtowicz, Joanna
(
Avtor
),
ID
Jekovec-Vrhovšek, Maja
(
Avtor
),
ID
Kałużna-Czaplińska, Joanna
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,13 MB)
MD5: FAAFA4E07169B259E35EF983FBDC0ABF
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1422-0067/24/8/7078
Galerija slik
Izvleček
Autism spectrum disorder (ASD) is a complex developmental disorder in which communication and behavior are affected. A number of studies have investigated potential biomarkers, including uremic toxins. The aim of our study was to determine uremic toxins in the urine of children with ASD (143) and compare the results with healthy children (48). Uremic toxins were determined with a validated high-performance liquid chromatography coupled to mass spectrometry (LC-MS/MS) method. We observed higher levels of p-cresyl sulphate (pCS) and indoxyl sulphate (IS) in the ASD group compared to the controls. Moreover, the toxin levels of trimethylamine N-oxide (TMAO), symmetric dimethylarginine (SDMA), and asymmetric dimethylarginine (ADMA) were lower in ASD patients. Similarly, for pCS and IS in children classified, according to the intensity of their symptoms, into mild, moderate, and severe, elevated levels of these compounds were observed. For mild severity of the disorder, elevated levels of TMAO and comparable levels of SDMA and ADMA for ASD children as compared to the controls were observed in the urine. For moderate severity of ASD, significantly elevated levels of TMAO but reduced levels of SDMA and ADMA were observed in the urine of ASD children as compared to the controls. When the results obtained for severe ASD severity were considered, reduced levels of TMAO and comparable levels of SDMA and ADMA were observed in ASD children.
Jezik:
Angleški jezik
Ključne besede:
uremic toxins
,
autism spectrum disorder
,
ASD
,
degree of deficit
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FFA - Fakulteta za farmacijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
14 str.
Številčenje:
Vol. 24, iss. 8, art. 7078
PID:
20.500.12556/RUL-145165
UDK:
616.896
ISSN pri članku:
1422-0067
DOI:
10.3390/ijms24087078
COBISS.SI-ID:
148468227
Datum objave v RUL:
12.04.2023
Število ogledov:
482
Število prenosov:
80
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Objavi na:
Gradivo je del revije
Naslov:
International journal of molecular sciences
Skrajšan naslov:
Int. j. mol. sci.
Založnik:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
uremični toksini
,
motnje avtističnega spektra
,
MAS
,
stopnja primanjkljaja
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
J3-1756
Naslov:
Okoljski in genetski dejavniki pri motnjah avtističnega spektra
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0124
Naslov:
Metabolni in prirojeni dejavniki reproduktivnega zdravja, porod III
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