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Candidate genes for mastitis resistance in dairy cattle : a data integration approach
ID Brajnik Kovačič, Zala (Author), ID Ogorevc, Jernej (Author)

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Abstract
Background Inflammation of the mammary tissue (mastitis) is one of the most detrimental health conditions in dairy ruminants and is considered the most economically important infectious disease of the dairy sector. Improving mastitis resistance is becoming an important goal in dairy ruminant breeding programmes. However, mastitis resistance is a complex trait and identification of mastitis-associated alleles in livestock is difficult. Currently, the only applicable approach to identify candidate loci for complex traits in large farm animals is to combine different information that supports the functionality of the identified genomic regions with respect to a complex trait. Methods To identify the most promising candidate loci for mastitis resistance we integrated heterogeneous data from multiple sources and compiled the information into a comprehensive database of mastitis-associated candidate loci. Mastitis-associated candidate genes reported in association, expression, and mouse model studies were collected by searching the relevant literature and databases. The collected data were integrated into a single database, screened for overlaps, and used for gene set enrichment analysis. Results The database contains candidate genes from association and expression studies and relevant transgenic mouse models. The 2448 collected candidate loci are evenly distributed across bovine chromosomes. Data integration and analysis revealed overlaps between different studies and/or with mastitis-associated QTL, revealing promising candidate genes for mastitis resistance. Conclusion Mastitis resistance is a complex trait influenced by numerous alleles. Based on the number of independent studies, we were able to prioritise candidate genes and propose a list of the 22 most promising. To our knowledge this is the most comprehensive database of mastitis associated candidate genes and could be helpful in selecting genes for functional validation studies.

Language:English
Keywords:association study, candidate genes, epigenetics, mammary gland, mastitis, quantitative trait loci
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:BF - Biotechnical Faculty
Publication status:Published
Publication version:Version of Record
Year:2023
Number of pages:14 str.
Numbering:Vol. 14, art. 10
PID:20.500.12556/RUL-145084 This link opens in a new window
UDC:636.2:575
ISSN on article:2049-1891
DOI:10.1186/s40104-022-00821-0 This link opens in a new window
COBISS.SI-ID:141296387 This link opens in a new window
Publication date in RUL:04.04.2023
Views:588
Downloads:91
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Record is a part of a journal

Title:Journal of animal science and biotechnology
Shortened title:J. anim. sci. biotechnol.
Publisher:Springer Nature, BioMed Central
ISSN:2049-1891
COBISS.SI-ID:523180569 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:govedoreja, govedo, krave, molznice, mastitis, genetika, kandidatni geni, QTL, baza podatkov

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P4-0220
Name:Primerjalna genomika in genomska biodiverziteta

Funder:ARRS - Slovenian Research Agency
Funding programme:Young researchers

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