20.500.12556/RUL-145084 Candidate genes for mastitis resistance in dairy cattle a data integration approach Background Inflammation of the mammary tissue (mastitis) is one of the most detrimental health conditions in dairy ruminants and is considered the most economically important infectious disease of the dairy sector. Improving mastitis resistance is becoming an important goal in dairy ruminant breeding programmes. However, mastitis resistance is a complex trait and identification of mastitis-associated alleles in livestock is difficult. Currently, the only applicable approach to identify candidate loci for complex traits in large farm animals is to combine different information that supports the functionality of the identified genomic regions with respect to a complex trait. Methods To identify the most promising candidate loci for mastitis resistance we integrated heterogeneous data from multiple sources and compiled the information into a comprehensive database of mastitis-associated candidate loci. Mastitis-associated candidate genes reported in association, expression, and mouse model studies were collected by searching the relevant literature and databases. The collected data were integrated into a single database, screened for overlaps, and used for gene set enrichment analysis. Results The database contains candidate genes from association and expression studies and relevant transgenic mouse models. The 2448 collected candidate loci are evenly distributed across bovine chromosomes. Data integration and analysis revealed overlaps between different studies and/or with mastitis-associated QTL, revealing promising candidate genes for mastitis resistance. Conclusion Mastitis resistance is a complex trait influenced by numerous alleles. Based on the number of independent studies, we were able to prioritise candidate genes and propose a list of the 22 most promising. To our knowledge this is the most comprehensive database of mastitis associated candidate genes and could be helpful in selecting genes for functional validation studies. association study candidate genes epigenetics mammary gland mastitis quantitative trait loci govedoreja govedo krave molznice mastitis genetika kandidatni geni QTL baza podatkov true false true Angleški jezik Slovenski jezik Članek v reviji 2023-04-04 13:40:58 2023-04-04 13:40:59 2024-02-26 14:08:37 0000-00-00 00:00:00 2023 0 0 14 str. art. 10 Vol. 14 2023 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 636.2:575 2049-1891 10.1186/s40104-022-00821-0 141296387 s40104-022-00821-0.pdf s40104-022-00821-0.pdf 1 D226B0397F5F876D5CA86D49A85D3558 018185867701f09c9f4f7323e3a25ee58091a73542a8b93755d50c2af4c25b2e 23d1783b-d2df-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167723 https://jasbsci.biomedcentral.com/articles/10.1186/s40104-022-00821-0 1 73117c96-d2dd-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=167722 Biotehniška fakulteta 0 0 0