The effect of design and size of the fluid-bed equipment on the particle size-dependent trend of particle coating thickness and drug prolonged-release profile
ID Brezovar, Teja (Author), ID Hudovornik, Grega (Author), ID Perpar, Matjaž (Author), ID Luštrik, Matevž (Author), ID Dreu, Rok (Author)

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The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates the drug release. In the first set of coating experiments, the pellet cores were coated with the Tartrazine dye with the aim of estimating the coating equipment performance in terms of coating thickness distribution, assessed through color hue. In the second set, drug-layered pellets were film-coated with prolonged-release coating and dissolution profile tests were performed to estimate the thickness and uniformity of the coating thickness among differently sized pellets. In both study parts, film coating was performed at the laboratory and the pilot scale and essentially two types of distribution plate and different height adjustments of the draft tube were compared. The dye coating study proved to be extremely useful, as the results enable process correction and the optimal use of the process equipment in combination with the appropriate process parameters. Preferential film coating of larger drug-containing pellets was confirmed on the laboratory scale, while on the pilot scale, it was possible to achieve preferential coating of smaller pellets using rational alternatives of settings, which is desirable in terms of particle size-independent drug release profile of such prolonged-release dosage forms.

Keywords:pellet film coating, Wurster chamber, swirl generator, prolonged release, preferential coating
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
FS - Faculty of Mechanical Engineering
MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Number of pages:16 str.
Numbering:Vol. 24, iss. 4, art. 93
PID:20.500.12556/RUL-145071 This link opens in a new window
ISSN on article:1530-9932
DOI:10.1208/s12249-023-02540-9 This link opens in a new window
COBISS.SI-ID:147500291 This link opens in a new window
Publication date in RUL:03.04.2023
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Record is a part of a journal

Title:AAPS PharmSciTech
Shortened title:AAPS PharmSciTech
Publisher:American Association of Pharmaceutical Scientists, Springer Nature
COBISS.SI-ID:1247345 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Keywords:peletna filmska prevleka, wursterjeva komora, vrtinčni generator, podaljšano sproščanje, prednostna prevleka, farmacevtska tehnologija, farmacevtske oblike


Funder:ARRS - Slovenian Research Agency
Project number:P1-0189
Name:Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

Funder:ARRS - Slovenian Research Agency
Project number:P2-0162
Name:Večfazni sistemi

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