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Kin discrimination promotes horizontal gene transfer between unrelated strains in Bacillus subtilis
ID
Štefanič, Polonca
(
Author
),
ID
Belcijan, Katarina
(
Author
),
ID
Kraigher, Barbara
(
Author
),
ID
Kostanjšek, Rok
(
Author
),
ID
Nesme, Joseph
(
Author
),
ID
Madsen, Jonas Stenløkke
(
Author
),
ID
Kovač, Jasna
(
Author
),
ID
Sørensen, Søren Johannes
(
Author
),
ID
Vos, Michiel
(
Author
),
ID
Mandić-Mulec, Ines
(
Author
)
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https://www.nature.com/articles/s41467-021-23685-w
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Abstract
Bacillus subtilis is a soil bacterium that is competent for natural transformation. Genetically distinct B. subtilis swarms form a boundary upon encounter, resulting in killing of one of the strains. This process is mediated by a fast-evolving kin discrimination (KD) system consisting of cellular attack and defence mechanisms. Here, we show that these swarm antagonisms promote transformation-mediated horizontal gene transfer between strains of low relatedness. Gene transfer between interacting non-kin strains is largely unidirectional, from killed cells of the donor strain to surviving cells of the recipient strain. It is associated with activation of a stress response mediated by sigma factor SigW in the donor cells, and induction of competence in the recipient strain. More closely related strains, which in theory would experience more efficient recombination due to increased sequence homology, do not upregulate transformation upon encounter. This result indicates that social interactions can override mechanistic barriers to horizontal gene transfer. We hypothesize that KD-mediated competence in response to the encounter of distinct neighbouring strains could maximize the probability of efficient incorporation of novel alleles and genes that have proved to function in a genomically and ecologically similar context.
Language:
English
Keywords:
bacterial genetics
,
microbial ecology
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
BF - Biotechnical Faculty
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
11 str.
Numbering:
Vol. 12, art. 3457
PID:
20.500.12556/RUL-144796
UDC:
579.22/.26:579.852.11
ISSN on article:
2041-1723
DOI:
10.1038/s41467-021-23685-w
COBISS.SI-ID:
62369539
Publication date in RUL:
13.03.2023
Views:
566
Downloads:
59
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Record is a part of a journal
Title:
Nature communications
Shortened title:
Nat. Commun.
Publisher:
Nature Publishing Group
ISSN:
2041-1723
COBISS.SI-ID:
2315876
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
Bacillus subtilis
,
mikrobne združbe
,
sorodstveno razlikovanje
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P4-0116
Name:
Mikrobiologija in biotehnologija živil in okolja
Funder:
ARRS - Slovenian Research Agency
Project number:
US/18-19-091
Funder:
ARRS - Slovenian Research Agency
Project number:
J4-9302
Name:
Raziskave medceličnih komunikacij v večceličnih skupnostih različnih izolatov bakterije iz rodu Bacillus
Funder:
ARRS - Slovenian Research Agency
Project number:
J4-8228
Name:
Vpliv socialnega in genetskega prepoznavanja sorodnikov na interakcije bakterij B. subtilis
Funder:
ARRS - Slovenian Research Agency
Project number:
J4-7637
Name:
Raziskave socialnih interakcij v biotehnološko in medicinsko pomembnih mikrobnih biofilmih
Funder:
ARRS - Slovenian Research Agency
Funding programme:
University infrastructural centre
Name:
Microscopy of biological samples
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