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Genetic variability in molecular pathways implicated in Alzheimer's disease : a comprehensive review
ID
Vogrinc, David
(
Avtor
),
ID
Goričar, Katja
(
Avtor
),
ID
Dolžan, Vita
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(3,68 MB)
MD5: B29A91ACFC36EA59638E5A328125C7EB
URL - Izvorni URL, za dostop obiščite
https://www.frontiersin.org/articles/10.3389/fnagi.2021.646901/full
Galerija slik
Izvleček
Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting a significant part of the population. The majority of AD cases occur in the elderly with a typical age of onset of the disease above 65 years. AD presents a major burden for the healthcare system and since population is rapidly aging, the burden of the disease will increase in the future. However, no effective drug treatment for a full-blown disease has been developed to date. The genetic background of AD is extensively studied; numerous genome-wide association studies (GWAS) identified significant genes associated with increased risk of AD development. This review summarizes more than 100 risk loci. Many of them may serve as biomarkers of AD progression, even in the preclinical stage of the disease. Furthermore, we used GWAS data to identify key pathways of AD pathogenesis: cellular processes, metabolic processes, biological regulation, localization, transport, regulation of cellular processes, and neurological system processes. Gene clustering into molecular pathways can provide background for identification of novel molecular targets and may support the development of tailored and personalized treatment of AD.
Jezik:
Angleški jezik
Ključne besede:
Alzheimer's disease
,
genetic risk factors
,
pathogenesis
,
genetics
,
biomarker
,
molecular pathways
,
gene ontology
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
30 str.
Številčenje:
Vol. 13, art. 646901
PID:
20.500.12556/RUL-144670
UDK:
616.8
ISSN pri članku:
1663-4365
DOI:
10.3389/fnagi.2021.646901
COBISS.SI-ID:
57793283
Datum objave v RUL:
07.03.2023
Število ogledov:
804
Število prenosov:
42
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Frontiers in aging neuroscience
Skrajšan naslov:
Front. aging neurosci.
Založnik:
Frontiers Media
ISSN:
1663-4365
COBISS.SI-ID:
20576008
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
Alzheimerjeva bolezen
,
genetski dejavniki tveganja
,
patogeneza
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0170
Naslov:
Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku
Financer:
EC - European Commission
Program financ.:
H2020
Številka projekta:
951851
Naslov:
Chair of Neuroinformatics
Akronim:
CONI
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