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The antibacterial effects of new N-alkylpyridinium salts on planktonic and biofilm bacteria
ID
Hympanova, Michaela
(
Avtor
),
ID
Terlep, Saša
(
Avtor
),
ID
Markova, Aneta
(
Avtor
),
ID
Prchal, Lukáš
(
Avtor
),
ID
Dogša, Iztok
(
Avtor
),
ID
Pulkrabkova, Lenka
(
Avtor
),
ID
Benkova, Marketa
(
Avtor
),
ID
Marek, Jan
(
Avtor
),
ID
Stopar, David
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(4,17 MB)
MD5: 0D816D3EDB0E0882216AF9C073227DA4
URL - Izvorni URL, za dostop obiščite
https://www.frontiersin.org/articles/10.3389/fmicb.2020.573951/full
Galerija slik
Izvleček
An increasing microbial resistance to known antibiotics raises a demand for new antimicrobials. In this study the antimicrobial properties of a series of new N-Alkylpyridinium quaternary ammonium compounds (QACs) with varying alkyl chain lengths were evaluated for several nosocomial pathogens. The chemical identities of the new QACs were determined by NMR, LC-MS, and HRMS. All the planktonic bacteria tested were susceptible to the new QACs as evaluated by MIC and MBC assays. The antimicrobial effect was most pronounced against Staphylococcus aureus clinical isolates. Live/dead staining CLSM was used to test the effectiveness of the QACs in biofilms. The effectiveness was up to 10-fold lower than in the plankton. When QACs were used as irrigants in Er:YAG – SSP photoacoustic steaming, their effectiveness significantly increased. The combined use of irrigants and photoacoustic streaming increased biofilm removal from the surface and increased the killing rate of the cells remaining on the surface. This may allow for a shorter chemical exposure time and lower dosage of QACs used in applications. The results demonstrate that the new QACs have potential to be applied as antibacterial compounds effective against planktonic and biofilm bacteria as well as irrigants in removal of difficult-to-reach biofilms.
Jezik:
Angleški jezik
Ključne besede:
antimicrobial activity
,
quaternary ammonium salts
,
bacteria
,
biofilm
,
photoacoustic irrigation
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
12 str.
Številčenje:
Vol. 11, art. 573951
PID:
20.500.12556/RUL-144646
UDK:
579.6
ISSN pri članku:
1664-302X
DOI:
10.3389/fmicb.2020.573951
COBISS.SI-ID:
33768963
Datum objave v RUL:
06.03.2023
Število ogledov:
462
Število prenosov:
60
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Frontiers in microbiology
Skrajšan naslov:
Front. microbiol.
Založnik:
Frontiers Research Foundation
ISSN:
1664-302X
COBISS.SI-ID:
4146296
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
biofilmi
,
bakterijski biofilmi
,
Staphylococcus aureus
,
kvarterne amonijeve spojine
,
protimikrobna aktivnost
Projekti
Financer:
EC - European Commission
Program financ.:
Erasmus, Lifelong Learning Programme
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0116
Naslov:
Mikrobiologija in biotehnologija živil in okolja
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Czech Republic, Ministry of Health
Številka projekta:
NV 19-09-00198
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Czech Republic, Ministry of Education, Youth and Sports
Številka projekta:
SV/FVZ201905
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
Faculty of Military Health Sciences, Long-term development plan
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