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Potential revival of cholinesterase inhibitors as drugs in veterinary medicine
ID
Žnidaršič, Neža
(
Avtor
),
ID
Štrbenc, Malan
(
Avtor
),
ID
Grgurevič, Neža
(
Avtor
),
ID
Snoj, Tomaž
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(882,63 KB)
MD5: 858AD2DFAEB7443BC36F46AC8CEBE7A9
URL - Izvorni URL, za dostop obiščite
https://www.frontiersin.org/articles/10.3389/fvets.2023.1125618/full
Galerija slik
Izvleček
The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes that enable the hydrolysis of acetylcholine and in this way ensure homeostasis in cholinergic synapses. Cholinesterase inhibitors (ChEi) are a group of indirect-acting cholinergic agonists that influence the activity of the cholinergic system. Several compounds that can inhibit cholinesterases are of importance to veterinary medicine from pharmacological and toxicological perspective. The frequency of their use in veterinary medicine has fluctuated over the years and is now reduced to a minimum. They are mainly used in agriculture as pesticides, and some are rarely used as parasiticides for companion animals and livestock. In recent years, interest in the use of new cholinesterase inhibitors has increased since canine cognitive dysfunction (CCD) became a recognized and extensively studied disease. Similar to Alzheimer’s disease (AD) in humans, CCD can be treated with cholinesterase inhibitors that cross the blood–brain barrier. In this review, the mammalian cholinergic system and the drugs that interact with cholinesterases are introduced. Cholinesterase inhibitors that can be used for the treatment of CCD are described in detail.
Jezik:
Angleški jezik
Ključne besede:
cholinergic system
,
cholinesterase inhibitors
,
organophosphates
,
carbamates
,
canine cognitive dysfunction
,
cognitive dysfunction
,
dogs
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
11 str.
Številčenje:
Vol. 10, art. 1125618
PID:
20.500.12556/RUL-144645
UDK:
636.09:577:612
ISSN pri članku:
2297-1769
DOI:
10.3389/fvets.2023.1125618
COBISS.SI-ID:
144140035
Datum objave v RUL:
06.03.2023
Število ogledov:
644
Število prenosov:
80
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Frontiers in veterinary science
Skrajšan naslov:
Front. vet. sci.
Založnik:
Frontiers Media S.A.
ISSN:
2297-1769
COBISS.SI-ID:
3969402
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0053
Naslov:
Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih
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