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Testing the extreme male hypothesis in the valproate mouse model; sex-specific effects on plasma testosterone levels and tyrosine hydroxylase expression in the anteroventral periventricular nucleus, but not on parental behavior
ID
Grgurevič, Neža
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,44 MB)
MD5: 831B8C616C48F38C85F6EFF8AB43F6B9
URL - Izvorni URL, za dostop obiščite
https://www.frontiersin.org/articles/10.3389/fnbeh.2023.1107226/full
Galerija slik
Izvleček
Introduction: Autism is a neurodevelopmental disorder with a strong male bias in prevalence and severity. The extreme male hypothesis proposed that autism is a manifestation of extreme male traits as evidenced by increased masculine behaviors, hypermasculinization of some brain regions, and alterations in androgen metabolism. In the present study, the extreme male hypothesis was tested in the valproate (VPA) mouse model. Methods: Females of the C57BL/6JOlaHsd mouse strain were treated with 500 mg/kg VPA on gestational day 12. Offspring of both sexes were tested at 3 to 4 months of age in the elevated plus maze (EPM), open field, sociability tests, and for parental behavior. After sacrifice at 5 to 6 months of age, plasma testosterone was measured in males, while the brains of both sexes were examined for tyrosine hydroxylase (TH) expression in the anteroventral periventricular nucleus (AVPV). Results: VPA treatment significantly increased plasma testosterone levels and decreased AVPV TH expression in males, whereas the expression of TH in females remained at the same level. In parental behavior test none of the pup-oriented behavior was affected by VPA treatment in both sexes, the exception was nest quality which was lower after VPA exposure in males, but not in females. Discussion: Our results suggest a hypermasculinizing effect of VPA that occurred specifically in males but not in females, and this effect could be related to changes in androgen physiology. Nevertheless, a generalized interpretation of the extreme male hypothesis on brain and behavior should be avoided due to the complex effects of VPA.
Jezik:
Angleški jezik
Ključne besede:
valproate
,
sex difference
,
parental behavior
,
tyrosine hydroxylase
,
autism
,
testosterone
,
mouse
,
valproic acid
,
sex characteristics
,
tyrosine 3-monooxygenase
,
autistic disorder
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
VF - Veterinarska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
10 str.
Številčenje:
Vol. 17, art. 1107226
PID:
20.500.12556/RUL-144472
UDK:
616.8
ISSN pri članku:
1662-5153
DOI:
10.3389/fnbeh.2023.1107226
COBISS.SI-ID:
142793731
Datum objave v RUL:
23.02.2023
Število ogledov:
640
Število prenosov:
75
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Objavi na:
Gradivo je del revije
Naslov:
Frontiers in behavioral neuroscience
Skrajšan naslov:
Front. behav. neurosci.
Založnik:
Frontiers Media
ISSN:
1662-5153
COBISS.SI-ID:
20809480
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
Z7-5516
Naslov:
Vpliv spolnih hormonov na spolne razlike pri motnjah avtističnega spektra na modelu miši
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0053
Naslov:
Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih
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