The central role of the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases

Poljšak, Borut (author), Kovač, Vito (author), Špalj, Stjepan (author), Milisav, Irina (author)

The molecule NAD+ is a coenzyme for enzymes catalyzing cellular redox reactions in several metabolic pathways, encompassing glycolysis, TCA cycle, and oxidative phosphorylation, and is a substrate for NAD+-dependent enzymes. In addition to a hydride and electron transfer in redox reactions, NAD+ is a substrate for sirtuins and poly(adenosine diphosphate–ribose) polymerases and even moderate decreases in its cellular concentrations modify signaling of NAD+-consuming enzymes. Age-related reduction in cellular NAD+ concentrations results in metabolic and aging-associated disorders, while the consequences of increased NAD+ production or decreased degradation seem beneficial. This article reviews the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases and discusses the strategies of NAD+ modulation for healthy aging and longevity.

• Language: English
• Keywords: NAD+ precursors, NAD+ levels, sirtuin, PARP
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: ZF - Faculty of Health Sciences; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Publication date: 01.01.2023
• Year: 2023
• Number of pages: 17 str.
• Numbering: Vol. 24, no. 3, art. 2959
• PID: 20.500.12556/RUL-144285
• UDC: 612.67/.68:577
• ISSN on article: 1661-6596
• DOI: 10.3390/ijms24032959
• COBISS.SI-ID: 141320707
• Publication date in RUL: 10.02.2023

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1661-6596
• COBISS.SI-ID: 36217605

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Undetermined
• Keywords: prekurzorji NAD+, ravni NAD+, sirtuin, PARP

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0388-2022
• Name: Mehanizmi varovanja zdravja

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0019-2019
• Name: Aplikativna in bazična fiziologija in patofiziologija v medicini