20.500.12556/RUL-144285 The central role of the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases The molecule NAD+ is a coenzyme for enzymes catalyzing cellular redox reactions in several metabolic pathways, encompassing glycolysis, TCA cycle, and oxidative phosphorylation, and is a substrate for NAD+-dependent enzymes. In addition to a hydride and electron transfer in redox reactions, NAD+ is a substrate for sirtuins and poly(adenosine diphosphate–ribose) polymerases and even moderate decreases in its cellular concentrations modify signaling of NAD+-consuming enzymes. Age-related reduction in cellular NAD+ concentrations results in metabolic and aging-associated disorders, while the consequences of increased NAD+ production or decreased degradation seem beneficial. This article reviews the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases and discusses the strategies of NAD+ modulation for healthy aging and longevity. NAD+ precursors NAD+ levels sirtuin PARP prekurzorji NAD+ ravni NAD+ sirtuin PARP true false true Angleški jezik Ni določen Članek v reviji 2023-02-10 14:10:45 2023-02-10 14:10:45 2023-02-11 03:35:36 0000-00-00 00:00:00 2023 0 0 17 str. no. 3, art. 2959 Vol. 24 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2023-01-01 612.67/.68:577 1661-6596 10.3390/ijms24032959 141320707 2023-NAD-modulation-ijms-24-02959.pdf 2023-NAD-modulation-ijms-24-02959.pdf 1 96CBFB44E2E1F0F00A05C930E5C1D1D6 72169240c8041dc700ac6e50922427b99dfe8b906e063517d75e3b3a52634757 348a282d-a944-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=166510 https://www.mdpi.com/1422-0067/24/3/2959 1 046a151d-a944-11ed-9c94-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=166509 Zdravstvena fakulteta Medicinska fakulteta 0 0 0