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Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion stability on the ocular surface
ID
Jurišić Dukovski, Bisera
(
Author
),
ID
Josip, Ljubica
(
Author
),
ID
Kocbek, Petra
(
Author
),
ID
Safundžić Kučuk, Maša
(
Author
),
ID
Krtalić, Iva
(
Author
),
ID
Hafner, Anita
(
Author
),
ID
Pepić, Ivan
(
Author
),
ID
Lovrić, Jasmina
(
Author
)
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https://www.sciencedirect.com/science/article/pii/S037851732300042X?via%3Dihub
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Abstract
Ophthalmic oil-in-water nanoemulsions (NEs) are a complex technological platform, representing an advancement in the treatment of dry eye disease. In addition to enabling the incorporation of poorly soluble active pharmaceutical ingredients (APIs), NEs provide prolonged residence time of APIs and other formulation components and consequent replenishment and stabilization of the compromised tear film. Ophthalmic NEs have been on the market for over 20 years, but considering their complexity, as well as the complex nature of the ocular surface, they are still a poorly understood advanced dosage form. The objective of this study was to develop a biorelevant in vitro method that would be able to predict the behavior of ophthalmic NEs after application. With that goal, NE formulations differing in critical material attributes and critical formulation variables were employed and subjected to simulated tear turnover and blinking. By gradually increasing the complexity of the in vitro method, we were able to detect key parameters influencing NE stability. The undertaken study presents a step forward in the development of in vitro tools that are fundamental to the reliable, cost and time-effective development of innovative and generic topical ophthalmic NEs.
Language:
English
Keywords:
eye drops
,
nanoemulsion
,
chitosan
,
dilution
,
high shear
,
dynamic light scattering
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2023
Number of pages:
11 str.
Numbering:
art. 122622, Vol. 633
PID:
20.500.12556/RUL-144061
UDC:
66.017-022.513.2:620.3
ISSN on article:
0378-5173
DOI:
10.1016/j.ijpharm.2023.122622
COBISS.SI-ID:
139859459
Publication date in RUL:
30.01.2023
Views:
460
Downloads:
102
Metadata:
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Record is a part of a journal
Title:
International journal of pharmaceutics
Shortened title:
Int. j. pharm.
Publisher:
Elsevier
ISSN:
0378-5173
COBISS.SI-ID:
3087631
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
kapljice za oko
,
nanoemulzije
,
dinamično sipanje svetlobe
,
visoko striženje
Projects
Funder:
HRZZ - Croatian Science Foundation
Project number:
IP-2019-04-2174
Name:
FarmInova
Funder:
Other - Other funder or multiple funders
Funding programme:
European Regional Development Fund
Project number:
KK.01.1.1.02.002
Name:
FarmInova
Funder:
HRZZ - Croatian Science Foundation
Project number:
DOK-2020-01-4932
Name:
Young researchers’ career development project – training of new doctoral students
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