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Antidepressive effect of natural products and their derivatives targeting BDNF-TrkB in gut–brain axis
ID Liaqat, Humna (Avtor), ID Parveen, Amna (Avtor), ID Kim, Sun Yeou (Avtor)

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Izvleček
Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.

Jezik:Angleški jezik
Ključne besede:BDNF, depression, TrkB, gut–brain axis, signaling pathways, natural products, microbiome
Vrsta gradiva:Članek v reviji
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:BF - Biotehniška fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2022
Št. strani:30 str.
Številčenje:Vol. 23, iss. 23, art. 14968
PID:20.500.12556/RUL-143574 Povezava se odpre v novem oknu
UDK:579
ISSN pri članku:1422-0067
DOI:10.3390/ijms232314968 Povezava se odpre v novem oknu
COBISS.SI-ID:132209155 Povezava se odpre v novem oknu
Datum objave v RUL:28.12.2022
Število ogledov:332
Število prenosov:57
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Gradivo je del revije

Naslov:International journal of molecular sciences
Skrajšan naslov:Int. j. mol. sci.
Založnik:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:mikrobiologija, os črevesje možgani, depresija, BDNF

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