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Antidepressive effect of natural products and their derivatives targeting BDNF-TrkB in gut–brain axis
ID
Liaqat, Humna
(
Avtor
),
ID
Parveen, Amna
(
Avtor
),
ID
Kim, Sun Yeou
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,25 MB)
MD5: 601CD5FB11852467BED510BB0C8D3D2A
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1422-0067/23/23/14968
Galerija slik
Izvleček
Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.
Jezik:
Angleški jezik
Ključne besede:
BDNF
,
depression
,
TrkB
,
gut–brain axis
,
signaling pathways
,
natural products
,
microbiome
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
30 str.
Številčenje:
Vol. 23, iss. 23, art. 14968
PID:
20.500.12556/RUL-143574
UDK:
579
ISSN pri članku:
1422-0067
DOI:
10.3390/ijms232314968
COBISS.SI-ID:
132209155
Datum objave v RUL:
28.12.2022
Število ogledov:
332
Število prenosov:
57
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Objavi na:
Gradivo je del revije
Naslov:
International journal of molecular sciences
Skrajšan naslov:
Int. j. mol. sci.
Založnik:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
mikrobiologija
,
os črevesje možgani
,
depresija
,
BDNF
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