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Neuroprotective natural products’ regulatory effects on depression via gut–brain axis targeting Tryptophan
ID
Liaqat, Humna
(
Avtor
),
ID
Parveen, Amna
(
Avtor
),
ID
Kim, Sun Yeou
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(4,57 MB)
MD5: 21129CA6C96F2FE88D5ED0E97184A65D
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2072-6643/14/16/3270
Galerija slik
Izvleček
L-tryptophan (Trp) contributes to regulating bilateral communication of the gut–brain axis. It undergoes three major metabolic pathways, which lead to formation of kynurenine, serotonin (5-HT), and indole derivatives (under the control of the microbiota). Metabolites from the principal Trp pathway, kynurenic acid and quinolinic acid, exhibit neuroprotective activity, while picolinic acid exhibits antioxidant activity, and 5-HT modulates appetite, sleep cycle, and pain. Abnormality in Trp plays crucial roles in diseases, including depression, colitis, ulcer, and gut microbiota-related dysfunctions. To address these diseases, the use of natural products could be a favorable alternative because they are a rich source of compounds that can modulate the activity of Trp and combat various diseases through modulating different signaling pathways, including the gut microbiota, kynurenine pathway, and serotonin pathway. Alterations in the signaling cascade pathways via different phytochemicals may help us explore the deep relationships of the gut–brain axis to study neuroprotection. This review highlights the roles of natural products and their metabolites targeting Trp in different diseases. Additionally, the role of Trp metabolites in the regulation of neuroprotective and gastroprotective activities is discussed. This study compiles the literature on novel, potent neuroprotective agents and their action mechanisms in the gut–brain axis and proposes prospective future studies to identify more pharmaceuticals based on signaling pathways targeting Trp.
Jezik:
Angleški jezik
Ključne besede:
L-tryptophan
,
5-HT
,
metabolites
,
phytochemicals
,
gut–brain axis
,
neuroprotective
,
gastroprotective
,
signaling pathways
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
40 str.
Številčenje:
iss. 16, art. 3270
PID:
20.500.12556/RUL-142152
UDK:
616:579
ISSN pri članku:
2072-6643
DOI:
10.3390/nu14163270
COBISS.SI-ID:
118270723
Datum objave v RUL:
21.10.2022
Število ogledov:
659
Število prenosov:
92
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Nutrients
Skrajšan naslov:
Nutrients
Založnik:
MDPI
ISSN:
2072-6643
COBISS.SI-ID:
2948140
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
medicina
,
bolezni
,
os črevesje možgani
,
črevesna mikrobiota
,
triptofan
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