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Tumour budding and poorly differentiated clusters in colon cancer – different manifestations of partial epithelial–mesenchymal transition
ID Pavlič, Ana (Avtor), ID Boštjančič, Emanuela (Avtor), ID Kavalar, Rajko (Avtor), ID Ilijevec, Bojan (Avtor), ID Bonin, Serena (Avtor), ID Zanconati, Fabrizio (Avtor), ID Zidar, Nina (Avtor)

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Izvleček
Morphological features including infiltrative growth, tumour budding (TB), and poorly differentiated clusters (PDCs) have a firmly established negative predictive value in colorectal cancer (CRC). Despite extensive research, the mechanisms underlying different tumour growth patterns remain poorly understood. The aim of this study was to investigate the involvement of epithelial–mesenchymal transition (EMT) in TB and PDCs in CRC. Using laser-capture microdissection, we obtained distinct parts of the primary CRC including TB, PDCs, expansive tumour front, and the central part of the tumour, and analysed the expression of EMT-related markers, i.e. the miR-200 family, ZEB1/2, RND3, and CDH1. In TB, the miR-200 family and CDH1 were significantly downregulated, while ZEB2 was significantly upregulated. In PDCs, miR-141, miR-200c, and CDH1 were significantly downregulated. No significant differences were observed in the expression of any EMT-related markers between the expansive tumour front and the central part of the tumour. Our results suggest that both TB and PDCs are related to partial EMT. Discrete differences in morphology and expression of EMT-related markers between TB and PDCs indicate that they represent different manifestations of partial EMT. TB seems to be closer to complete EMT than PDCs.

Jezik:Angleški jezik
Ključne besede:colon cancer, colorectal cancer, epitheliall–mesenchymal transition, miRNA, partial epithelial–mesenchymal transition, poorly differentiated clusters, tumour budding
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2022
Št. strani:Str. 278-288
Številčenje:Vol. 258, iss. 3
PID:20.500.12556/RUL-141977 Povezava se odpre v novem oknu
UDK:616
ISSN pri članku:0022-3417
DOI:10.1002/path.5998 Povezava se odpre v novem oknu
COBISS.SI-ID:121432323 Povezava se odpre v novem oknu
Datum objave v RUL:13.10.2022
Število ogledov:573
Število prenosov:192
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:The journal of pathology
Skrajšan naslov:J. pathol.
Založnik:Wiley, The Pathological Society of Great Britain and Ireland
ISSN:0022-3417
COBISS.SI-ID:4745738 Povezava se odpre v novem oknu

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:rak debelega črevesa, kolorektalni rak, epitelno-mezenhimski prehod

Projekti

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P3-0054
Naslov:Patologija in molekularna genetika

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J3-1754
Naslov:Novi prognostični in diagnostični označevalci v razvoju raka debelega črevesa in danke

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