Effects of coenzyme Q$_{10}$ supplementation on oxidative stress markers, inflammatory markers, lymphocyte subpopulations, and clinical status in dogs with myxomatous mitral valve disease

Druzhaeva, Natalia (author), Nemec Svete, Alenka (author), Tavčar-Kalcher, Gabrijela (author), Babič, Janja (author), Ihan, Alojz (author), Pohar, Katka (author), Krapež, Uroš (author), Domanjko-Petrič, Aleksandra (author)

Scarce data exist on the effects of coenzyme Q$_{10}$ (CoQ$_{10}$) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ$_{10}$ supplementation on oxidative stress markers (glutathione peroxidase, F2-isoprostanes), markers of inflammation (tumor necrosis factor-α, TNF soluble receptor II, leucocytes, and their subtypes), lymphocyte subpopulations (T helper and cytotoxic T lymphocytes, including activated T lymphocytes, and B lymphocytes), and echocardiographic and clinical parameters in dogs with MMVD. In this randomized, controlled, double-blind, longitudinal study, 43 MMVD dogs in stages ACVIM (American College of Veterinary Internal Medicine classification) B2 and ACVIM C and D (congestive heart failure (CHF)) received water-soluble coenzyme Q$_{10}$ (100 mg twice daily) or placebo for 3 months, and 12 non-supplemented healthy dogs served as controls. All parameters were measured before and after supplementation in MMVD dogs and once in healthy dogs. CoQ$_{10}$ supplementation had a positive impact on neutrophil percentage, lymphocyte percentage, and lymphocyte concentration in our cohort of dogs with CHF (ACVIM C and D). Conclusion: CoQ$_{10}$ as an oral supplement may have benefits in terms of decreasing inflammation in dogs with MMVD and CHF.

• Language: English
• Keywords: coenzyme Q$_{10}$, ubiquinone, supplementation, myxomatous mitral valve disease, congestive heart failure, dog, oxidative stress, inflammation, lymphocytes, neutrophils, coenzymes, heart failure
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 22 str.
• Numbering: Vol. 11, iss. 8, art. 1427
• PID: 20.500.12556/RUL-138596
• UDC: 636.7.09:577:616
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox11081427
• COBISS.SI-ID: 116770819
• Publication date in RUL: 02.08.2022

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P4-0053
• Name: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih