20.500.12556/RUL-138596 Effects of coenzyme Q$_{10}$ supplementation on oxidative stress markers, inflammatory markers, lymphocyte subpopulations, and clinical status in dogs with myxomatous mitral valve disease Scarce data exist on the effects of coenzyme Q$_{10}$ (CoQ$_{10}$) supplementation in dogs with myxomatous mitral valve disease (MMVD). The purpose of this study was to investigate the effect of CoQ$_{10}$ supplementation on oxidative stress markers (glutathione peroxidase, F2-isoprostanes), markers of inflammation (tumor necrosis factor-α, TNF soluble receptor II, leucocytes, and their subtypes), lymphocyte subpopulations (T helper and cytotoxic T lymphocytes, including activated T lymphocytes, and B lymphocytes), and echocardiographic and clinical parameters in dogs with MMVD. In this randomized, controlled, double-blind, longitudinal study, 43 MMVD dogs in stages ACVIM (American College of Veterinary Internal Medicine classification) B2 and ACVIM C and D (congestive heart failure (CHF)) received water-soluble coenzyme Q$_{10}$ (100 mg twice daily) or placebo for 3 months, and 12 non-supplemented healthy dogs served as controls. All parameters were measured before and after supplementation in MMVD dogs and once in healthy dogs. CoQ$_{10}$ supplementation had a positive impact on neutrophil percentage, lymphocyte percentage, and lymphocyte concentration in our cohort of dogs with CHF (ACVIM C and D). Conclusion: CoQ$_{10}$ as an oral supplement may have benefits in terms of decreasing inflammation in dogs with MMVD and CHF. coenzyme Q$_{10}$ ubiquinone supplementation myxomatous mitral valve disease congestive heart failure dog oxidative stress inflammation lymphocytes neutrophils coenzymes heart failure true false true Angleški jezik Ni določen Članek v reviji 2022-08-02 10:25:42 2022-08-02 10:25:44 2023-05-16 03:32:37 0000-00-00 00:00:00 2022 0 0 22 str. iss. 8, art. 1427 Vol. 11 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 636.7.09:577:616 2076-3921 10.3390/antiox11081427 116770819 antioxidants-11-01427-v2.pdf antioxidants-11-01427-v2.pdf 1 CC92FD434DADF93F2ED55C1E25C6F151 c8b8b8cdb48fa1745b5854282b9de5cd0a43086738ced33c0cf4cec449217022 9d64d503-f2f6-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168817 https://www.mdpi.com/2076-3921/11/8/1427 1 77b38afe-123c-11ed-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=158965 Veterinarska fakulteta Medicinska fakulteta 0 0 0