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Complex osteochondral lesions of the talus treated with a novel bi-phasic aragonite-based implant
ID
Drobnič, Matej
(
Avtor
),
ID
Kolar, Matic
(
Avtor
),
ID
Verdonk, Peter
(
Avtor
),
ID
Vannini, Francesca
(
Avtor
),
ID
Robinson, Dror
(
Avtor
),
ID
Altschuler, Nir
(
Avtor
),
ID
Shabshin, Nogah
(
Avtor
),
ID
Kon, Elizaveta
(
Avtor
)
PDF - Predstavitvena datoteka,
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(785,53 KB)
MD5: 9BDEFAB69EAF515AAB5B04C171C25A4F
URL - Izvorni URL, za dostop obiščite
https://www.sciencedirect.com/science/article/pii/S1067251620303380
Galerija slik
Izvleček
To present initial results of a novel, bi-phasic, porous, biodegrade, and cell-free aragonite-based scaffold for treating complex osteochondral lesions of the talus (OLT). Four subjects (2 males and 2 females; 34-61 years old) were operated on their ankles due to chronic and deep OLT-Hepple grades 4 or 5 (1.8-2.2 cm$^2$). Three subjects had OLT on the medial central trochlea, and 1 had a combined medial and lateral lesions. OLT were exposed through medial malleolus osteotomy, with an additional lateral arthrotomy in the combined lesions. Bi-phasic porous osteochondral scaffolds (single implant or 2 implants) were implanted in a press-fit manner using a designated surgical toolset. Treatment outcome was followed clinically (Foot and Ankle Outcome Score, EQ-5D 3L, Tegner activity scale) and by medical imaging (radiographs, magnetic resonance imaging) from 18 to 32 months. All Foot and Ankle Outcome Score values increased from preoperative to final follow-up values (Symptoms 62 to 71, Pain 53 to 84, ADL 60 to 89, Sport 19 to 65, and QoL 18 to 47). EQ-5D 3L increased from 0.59 to 0.76, and Tegner activity values increased from 1.5 to 3. Kellgren-Lawrence ankle radiographic scores remained stable (2 to 2). Postoperative MR evaluation demonstrated cartilage defect fill of 75% to 100% respect to the native cartilage in 3 subjects (4 OLTs), while 1 lesion was filled 25% to 50%. No graft related serious adverse events or graft failures were reported. The use of a bi-phasic osteochondral biodegradable aragonite-based scaffold in the treatment of complex OLT during the reported period presented positive and promising clinical and radiologic outcome, without serious adverse events or graft failures.
Jezik:
Angleški jezik
Ključne besede:
Agili-C™
,
ankle
,
aragonite
,
biodegradable implants
,
bi-phasic implants
,
cartilage
,
osteochondral lesions
,
scaffold
,
talus
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
Str. 391-395
Številčenje:
Vol. 60, iss. 2
PID:
20.500.12556/RUL-138433
UDK:
617.3
ISSN pri članku:
1067-2516
DOI:
10.1053/j.jfas.2020.06.028
COBISS.SI-ID:
108232451
Datum objave v RUL:
20.07.2022
Število ogledov:
575
Število prenosov:
71
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Objavi na:
Gradivo je del revije
Naslov:
The journal of foot and ankle surgery
Skrajšan naslov:
J. foot ankle surg.
Založnik:
Elsevier, American College of Foot and Ankle Surgeons
ISSN:
1067-2516
COBISS.SI-ID:
1498431
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
ortopedija
,
nartnica
,
kirurgija
,
osteohondralne lezije talusa
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