Vaš brskalnik ne omogoča JavaScript!
JavaScript je nujen za pravilno delovanje teh spletnih strani. Omogočite JavaScript ali pa uporabite sodobnejši brskalnik.
Nacionalni portal odprte znanosti
Odprta znanost
DiKUL
slv
|
eng
Iskanje
Brskanje
Novo v RUL
Kaj je RUL
V številkah
Pomoč
Prijava
The possible influence of genetic aetiological factors on molar–incisor hypomineralisation
ID
Hočevar, Luka
(
Avtor
),
ID
Kovač, Jernej
(
Avtor
),
ID
Trebušak Podkrajšek, Katarina
(
Avtor
),
ID
Battelino, Saba
(
Avtor
),
ID
Pavlič, Alenka
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,05 MB)
MD5: 426EB65889D403E164BC79A25E3D9308
URL - Izvorni URL, za dostop obiščite
https://www.sciencedirect.com/science/article/pii/S0003996920302260
Galerija slik
Izvleček
Objective: The present study searched for evidence of possible associations between some genetic factors that could affect the development of molar–incisor hypomineralisation (MIH). Methods: In 113 patients who were surgically treated at an Otorhinolaryngology and Cervicofacial Surgery Clinic (ORL) during early childhood, human leukocyte antigen (HLA) DQ2 and DQ8 haplotypes and single nucleotide polymorphisms (SNP) of eight amelogenesis-related genes were searched in genomic DNA. Genotypes were determined by high resolution melting (HRM), TaqMan genotyping assays, and Sanger sequencing. Association between MIH and the HLA DQ2 and DQ8 alleles was tested using a univariate logistic regression. The significance of genetic variants was analysed using the Cochran–Armitage tests for trend and the Fisher exact tests. Results: We identified MIH in 22 (19.5 %) of the 113 children. Among the evaluated genetic variants, SNP rs2245803 in the MMP20 gene in a homozygous form in a recessive model was associated with MIH development (OR, 2.796; 95 %CI, 1.075 − 4.783; p = 0.0496) with the genotype distribution of TT(3), TG(6) or GG(13) in children with MIH and distribution of TT(18), TG(42) or GG(31) in children without MIH. Conclusions: While the aetiology of MIH remains unclear, our findings suggest that variants of genes associated with amelogenesis may play important roles in susceptibility to MIH.
Jezik:
Angleški jezik
Ključne besede:
molar–incisor hypomineralisation
,
aetiology
,
single nucleotide polymorphism
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2020
Št. strani:
8 str.
Številčenje:
Vol. 118, art. 104848
PID:
20.500.12556/RUL-138422
UDK:
616.31
ISSN pri članku:
1879-1506
DOI:
10.1016/j.archoralbio.2020.104848
COBISS.SI-ID:
25585923
Datum objave v RUL:
20.07.2022
Število ogledov:
525
Število prenosov:
82
Metapodatki:
Citiraj gradivo
Navadno besedilo
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Kopiraj citat
Objavi na:
Gradivo je del revije
Naslov:
Archives of oral biology
Založnik:
Elsevier
ISSN:
1879-1506
COBISS.SI-ID:
23196421
Licence
Licenca:
CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:
Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
20150115
Podobna dela
Podobna dela v RUL:
Podobna dela v drugih slovenskih zbirkah:
Nazaj