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Enhanced detection of cardiac surgery-associated acute kidney injury by composite biomarker panel in patients with normal preoperative kidney function
ID Kališnik, Jurij-Matija (Author), ID Steblovnik, Klemen (Author), ID Hrovat, Eva (Author), ID Jerin, Aleš (Author), ID Skitek, Milan (Author), ID Dinges, Christian (Author), ID Fischlein, Theodor (Author), ID Žibert, Janez (Author)

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Abstract
We have shown recently that minor subclinical creatinine dynamic changes enable excellent de-tection of acute kidney injury (AKI) within 6-12 hours after cardiac surgery. The aim of the pre-sent study was to examine combination of neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CysC) and creatinine for enhanced AKI detection early after cardiac surgery. Elective patients with normal renal function undergoing cardiac surgery using cardiopulmonary bypass were enrolled. Concentrations of plasma NGAL, serum CysC and serum creatinine concentra-tions were determined after induction of general anaesthesia, at termination of cardiopulmo-nary bypass and 2 hours thereafter. Out of 119 enrolled patients 51 (43%) developed AKI. A model utilizing NGAL, CysC and creatinine triple biomarker panel including sequential rela-tive changes provides better prediction of cardiac surgery-associated acute kidney injury then any biomarker alone already 2 hours after the termination of cardiopulmonary bypass. The area under receiver-operator curve was 0.77, sensitivity 77% and specificity 68%.

Language:English
Keywords:acute kidney injury, biomarker, cardiac surgery
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
FFA - Faculty of Pharmacy
ZF - Faculty of Health Sciences
Publication status:Published
Publication version:Version of Record
Year:2022
Number of pages:10 str.
Numbering:Vol. 9, iss. 7, art. 210
PID:20.500.12556/RUL-137815-3191c83c-18e3-4c6b-f97c-741488643b1e This link opens in a new window
UDC:616.12-089:616.61
ISSN on article:2308-3425
DOI:10.3390/jcdd9070210 This link opens in a new window
COBISS.SI-ID:107842819 This link opens in a new window
Publication date in RUL:01.07.2022
Views:864
Downloads:136
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Record is a part of a journal

Title:Journal of cardiovascular development and disease
Shortened title:J. cardiovasc. dev. dis.
Publisher:MDPI AG
ISSN:2308-3425
COBISS.SI-ID:523193113 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:akutna poškodba ledvic, biomarkerji, srčna kirurgija, biološki označevalci, ledvice

Projects

Funder:Other - Other funder or multiple funders
Funding programme:University Medical Centre Ljubljana
Project number:20100605

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