20.500.12556/RUL-137815 Enhanced detection of cardiac surgery-associated acute kidney injury by composite biomarker panel in patients with normal preoperative kidney function We have shown recently that minor subclinical creatinine dynamic changes enable excellent de-tection of acute kidney injury (AKI) within 6-12 hours after cardiac surgery. The aim of the pre-sent study was to examine combination of neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CysC) and creatinine for enhanced AKI detection early after cardiac surgery. Elective patients with normal renal function undergoing cardiac surgery using cardiopulmonary bypass were enrolled. Concentrations of plasma NGAL, serum CysC and serum creatinine concentra-tions were determined after induction of general anaesthesia, at termination of cardiopulmo-nary bypass and 2 hours thereafter. Out of 119 enrolled patients 51 (43%) developed AKI. A model utilizing NGAL, CysC and creatinine triple biomarker panel including sequential rela-tive changes provides better prediction of cardiac surgery-associated acute kidney injury then any biomarker alone already 2 hours after the termination of cardiopulmonary bypass. The area under receiver-operator curve was 0.77, sensitivity 77% and specificity 68%. acute kidney injury biomarker cardiac surgery akutna poškodba ledvic biomarkerji srčna kirurgija biološki označevalci ledvice true false true Angleški jezik Slovenski jezik Članek v reviji 2022-07-01 12:28:16 2022-07-01 12:28:22 2025-08-08 13:20:42 0000-00-00 00:00:00 2022 0 0 10 str. iss. 7, art. 210 Vol. 9 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.12-089:616.61 2308-3425 10.3390/jcdd9070210 107842819 jcdd-09-00210.pdf jcdd-09-00210.pdf 1 90C418B588E963B94E52153986D3759F 6d767f77f827f9358531b6eba1d49f15a8510bac10c33475d6f5236437227138 fe3b7dc2-f928-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157901 https://www.mdpi.com/2308-3425/9/7/210 1 5371029b-f928-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157900 Medicinska fakulteta Fakulteta za farmacijo Zdravstvena fakulteta 0 0 0