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The impact of SARS-CoV-2 primary vaccination in a cohort of patients hospitalized for acute COVID-19 during Delta variant predominance
ID
Stupica, Daša
(
Author
),
ID
Collinet-Adler, Stefan
(
Author
),
ID
Kejžar, Nataša
(
Author
),
ID
Jagodic, Zala
(
Author
),
ID
Poljak, Mario
(
Author
),
ID
Nahtigal Klevišar, Mirijam
(
Author
)
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MD5: 05256BA6B0533FA1EBDCAF61ED12D9EB
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https://www.mdpi.com/2077-0383/11/5/1191
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Abstract
Vaccine breakthrough SARS-CoV-2 infections necessitating hospitalization have emerged as a relevant problem with longer time interval since vaccination and the predominance of the Delta variant. The aim of this study was to evaluate the association between primary vaccination with four SARS-CoV-2 vaccines authorized for use in the European Union—BNT162b2, ChAdOx-1S, mRNA-1273 or Ad.26.COV2.S—and progression to critically severe disease (mechanical ventilation or death) and duration of hospitalization among adult patients with PCR-confirmed acute COVID-19 hospitalized during the Delta variant predominance (October–November 2021) in Slovenia. Among the 529 enrolled patients hospitalized with COVID-19 (median age, 65 years; 58.2% men), 175 (33.1%) were fully vaccinated at the time of symptom onset. Compared with 345 unvaccinated patients, fully vaccinated patients with breakthrough infections were older, more often immunocompromised, and had higher Charlson comorbidity index scores. After adjusting for sex, age, and comorbidities, fully vaccinated patients had lower odds for progressing to critically severe disease and were discharged from the hospital earlier than unvaccinated patients. Vaccination against SARS-CoV-2 remains an extremely effective intervention to alleviate morbidity and mortality in COVID-19 patients.
Language:
English
Keywords:
COVID-19 vaccine
,
vaccine breakthrough
,
vaccination impact
,
COVID-19 outcome
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
MF - Faculty of Medicine
Publication status:
Published
Publication version:
Version of Record
Year:
2022
Number of pages:
10 str.
Numbering:
Vol. 11, iss. 5, art. 1191
PID:
20.500.12556/RUL-137279
UDC:
616.9
ISSN on article:
2077-0383
DOI:
10.3390/jcm11051191
COBISS.SI-ID:
98584067
Publication date in RUL:
09.06.2022
Views:
1264
Downloads:
101
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Record is a part of a journal
Title:
Journal of clinical medicine
Shortened title:
J. clin. med.
Publisher:
MDPI
ISSN:
2077-0383
COBISS.SI-ID:
5405759
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.03.2022
Secondary language
Language:
Slovenian
Keywords:
cepivo za COVID-19
,
preboj cepiva
,
vpliv cepljenja
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P3-0154
Name:
Metodologija za analizo podatkov v medicini
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