20.500.12556/RUL-137279 The impact of SARS-CoV-2 primary vaccination in a cohort of patients hospitalized for acute COVID-19 during Delta variant predominance Vaccine breakthrough SARS-CoV-2 infections necessitating hospitalization have emerged as a relevant problem with longer time interval since vaccination and the predominance of the Delta variant. The aim of this study was to evaluate the association between primary vaccination with four SARS-CoV-2 vaccines authorized for use in the European Union—BNT162b2, ChAdOx-1S, mRNA-1273 or Ad.26.COV2.S—and progression to critically severe disease (mechanical ventilation or death) and duration of hospitalization among adult patients with PCR-confirmed acute COVID-19 hospitalized during the Delta variant predominance (October–November 2021) in Slovenia. Among the 529 enrolled patients hospitalized with COVID-19 (median age, 65 years; 58.2% men), 175 (33.1%) were fully vaccinated at the time of symptom onset. Compared with 345 unvaccinated patients, fully vaccinated patients with breakthrough infections were older, more often immunocompromised, and had higher Charlson comorbidity index scores. After adjusting for sex, age, and comorbidities, fully vaccinated patients had lower odds for progressing to critically severe disease and were discharged from the hospital earlier than unvaccinated patients. Vaccination against SARS-CoV-2 remains an extremely effective intervention to alleviate morbidity and mortality in COVID-19 patients. COVID-19 vaccine vaccine breakthrough vaccination impact COVID-19 outcome cepivo za COVID-19 preboj cepiva vpliv cepljenja true false true Angleški jezik Slovenski jezik Članek v reviji 2022-06-09 11:09:36 2022-06-09 11:09:41 2022-09-15 04:14:53 0000-00-00 00:00:00 2022 0 0 10 str. iss. 5, art. 1191 Vol. 11 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2077-0383 10.3390/jcm11051191 98584067 jcm-11-01191.pdf jcm-11-01191.pdf 1 05256BA6B0533FA1EBDCAF61ED12D9EB 16358ea9f77420ef668fb55f25a3f1490ca342f4bb51eefb50159276dfd0e3ae 315df2f7-e7d4-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157184 https://www.mdpi.com/2077-0383/11/5/1191 0 f1628c31-e7d3-11ec-8aca-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=157183 Medicinska fakulteta 0 0 0