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Cervical intraepithelial neoplasia grade 3 in a HPV-vaccinated patient : a case report
ID
Sladič, Mateja
(
Avtor
),
ID
Taneska, Pepita
(
Avtor
),
ID
Cvjetičanin, Branko
(
Avtor
),
ID
Velikonja, Mojca
(
Avtor
),
ID
Smrkolj, Vladimir
(
Avtor
),
ID
Smrkolj, Špela
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(16,44 MB)
MD5: 1104256810D8CD244FC108B6C39EE512
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1648-9144/58/3/339
Galerija slik
Izvleček
Persistent infection with human papillomavirus (HPV) causes almost all cervical precancerous lesions and cancers. Bivalent, quadrivalent, and nonavalent HPV vaccines effectively prevent high-grade cervical intraepithelial neoplasia (CIN3). The effectiveness of HPV vaccination against CIN3 is 97–100% in HPV-naïve populations and 44–61% in the overall population. Although HPV vaccination has substantially reduced the incidence of cervical cancers, several cases of precancerous cervical lesions in HPV-vaccinated patients have been reported. We report the clinical case of a 19-year-old woman whose first Pap smear was diagnosed as a high-grade squamous intraepithelial lesion (HSIL) after quadrivalent HPV vaccination. Colposcopy and cervical biopsy were performed, revealing HSIL/CIN3. Our multidisciplinary team decided to take a conservative approach with follow-up visits with cervical biopsies of this young patient. After six months, spontaneous regression of high-grade cervical dysplasia was observed. Although HPV immunization has shown to be extremely effective in preventing a high proportion of cervical precancerous lesions and cervical cancers, HPV vaccines do not protect against all oncogenic high-risk HPV genotypes. Consequently, healthcare providers must encourage HPV-vaccinated women to still regularly attend national cervical screening programs.
Jezik:
Angleški jezik
Ključne besede:
papillomavirus vaccines
,
Papanicolaou test
,
cervical intraepithelial neoplasia
Vrsta gradiva:
Članek v reviji
Tipologija:
1.03 - Drugi znanstveni članki
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
7 str.
Številčenje:
Vol. 58, iss. 3, art. 339
PID:
20.500.12556/RUL-137257
UDK:
618.1
ISSN pri članku:
1648-9144
DOI:
10.3390/medicina58030339
COBISS.SI-ID:
98924803
Datum objave v RUL:
08.06.2022
Število ogledov:
684
Število prenosov:
81
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Objavi na:
Gradivo je del revije
Naslov:
Medicina
Založnik:
MDPI
ISSN:
1648-9144
COBISS.SI-ID:
6754623
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.03.2022
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
cepljenje proti papilomavirusu
,
maternični vrat
,
rak materničnega vratu
,
intraepitelna neoplazija
,
ginekologija
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