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Renal tissue miRNA expression profiles in ANCA-associated vasculitis—a comparative analysis
ID
Bošnjak, Matic
(
Avtor
),
ID
Večerić-Haler, Željka
(
Avtor
),
ID
Boštjančič, Emanuela
(
Avtor
),
ID
Kojc, Nika
(
Avtor
)
PDF - Predstavitvena datoteka,
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(1,02 MB)
MD5: D3333EA7E90D767527F8F95CC5CCAE97
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1422-0067/23/1/105
Galerija slik
Izvleček
Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) comprises autoimmune disease entities that cause target organ damage due to relapsing-remitting small vessel necrotizing vasculitis, and which affects various vascular beds. The pathogenesis of AAV is incompletely understood, which translates to considerable disease- and treatment-related morbidity and mortality. Recent advances have implicated microRNAs (miRNAs) in AAV; however, their accurate characterization in renal tissue is lacking. The goal of this study was to identify the intrarenal miRNA expression profile in AAV relative to healthy, non-inflammatory and inflammatory controls to identify candidate-specific miRNAs. Formalin-fixed, paraffin-embedded renal biopsy tissue samples from 85 patients were obtained. Comprehensive miRNA expression profiles were performed using panels with 752 miRNAs and revealed 17 miRNA that differentiated AAV from both controls. Identified miRNAs were annotated to characterize their involvement in pathways and to define their targets. A considerable subset of differentially expressed miRNAs was related to macrophage and lymphocyte polarization and cytokines previously deemed important in AAV pathogenesis, lending credence to the obtained results. Interestingly, several members of the miR-30 family were detected. However, a validation study of these differentially expressed miRNAs in an independent, larger sample cohort is needed to establish their potential diagnostic utility.
Jezik:
Angleški jezik
Ključne besede:
microRNA
,
screening
,
vasculitis
,
ANCA
,
glomerulonephritis
,
epigenetics
,
pathogenesis
,
biomarker
,
renal disease
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
15 str.
Številčenje:
Vol. 23, iss. 1, art. 105
PID:
20.500.12556/RUL-136912
UDK:
616
ISSN pri članku:
1422-0067
DOI:
10.3390/ijms23010105
COBISS.SI-ID:
92678915
Datum objave v RUL:
24.05.2022
Število ogledov:
607
Število prenosov:
107
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
International journal of molecular sciences
Skrajšan naslov:
Int. j. mol. sci.
Založnik:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.01.2022
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
mikroRNA
,
presejanje
,
vaskulitis
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0054
Naslov:
Patologija in molekularna genetika
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