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Pathophysiology of lipid droplets in neuroglia
ID
Smolič, Tina
(
Avtor
),
ID
Zorec, Robert
(
Avtor
),
ID
Vardjan, Nina
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,08 MB)
MD5: 67C9ADC34B23581B52C13AEBEE45C9E7
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2076-3921/11/1/22
Galerija slik
Izvleček
In recent years, increasing evidence regarding the functional importance of lipid droplets (LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged. Although not abundantly present in the CNS under normal conditions in adulthood, LDs accumulate in the CNS during development and aging, as well as in some neurologic disorders. LDs are actively involved in cellular lipid turnover and stress response. By regulating the storage of excess fatty acids, cholesterol, and ceramides in addition to their subsequent release in response to cell needs and/or environmental stressors, LDs are involved in energy production, in the synthesis of membranes and signaling molecules, and in the protection of cells against lipotoxicity and free radicals. Accumulation of LDs in the CNS appears predominantly in neuroglia (astrocytes, microglia, oligodendrocytes, ependymal cells), which provide trophic, metabolic, and immune support to neuronal networks. Here we review the most recent findings on the characteristics and functions of LDs in neuroglia, focusing on astrocytes, the key homeostasis-providing cells in the CNS. We discuss the molecular mechanisms affecting LD turnover in neuroglia under stress and how this may protect neural cell function. We also highlight the role (and potential contribution) of neuroglial LDs in aging and in neurologic disorders.
Jezik:
Angleški jezik
Ključne besede:
neuroglia
,
astrocytes
,
metabolic and oxidative stress
,
lipid droplets
,
neurologic disorders
,
pathophysiology
Vrsta gradiva:
Članek v reviji
Tipologija:
1.02 - Pregledni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2022
Št. strani:
21 str.
Številčenje:
Vol. 11, iss. 1, art. 22
PID:
20.500.12556/RUL-136910
UDK:
616-092
ISSN pri članku:
2076-3921
DOI:
10.3390/antiox11010022
COBISS.SI-ID:
92307971
Datum objave v RUL:
24.05.2022
Število ogledov:
579
Število prenosov:
102
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Antioxidants
Skrajšan naslov:
Antioxidants
Založnik:
MDPI
ISSN:
2076-3921
COBISS.SI-ID:
522976025
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.01.2022
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
nevroglija
,
astrociti
,
presnovni in oksidativni stres
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P3-0310
Naslov:
Celična fiziologija
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
J3-2523
Naslov:
Disregulacija presnove v astrogliji pri nevrodegeneraciji
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
COST
Številka projekta:
CA18133
Akronim:
ERNEST
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
COST
Številka projekta:
CA18240
Akronim:
Adher’n Rise
Financer:
Drugi - Drug financer ali več financerjev
Program financ.:
CipKeBip
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