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Current technologies for RNA-directed liquid diagnostics
ID Martinez-Dominguez, Maria Victoria (Author), ID Zottel, Alja (Author), ID Šamec, Neja (Author), ID Jovchevska, Ivana (Author), ID Dincer, Can (Author), ID Kahlert, Ulf Dietrich (Author), ID Nickel, Ann-Christin (Author)

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Abstract
There is unequivocal acceptance of the variety of enormous potential liquid nucleic acid-based diagnostics seems to offer. However, the existing controversies and the increased awareness of RNA-based techniques in society during the current global COVID-19 pandemic have made the readiness of liquid nucleic acid-based diagnostics for routine use a matter of concern. In this regard—and in the context of oncology—our review presented and discussed the status quo of RNA-based liquid diagnostics. We summarized the technical background of the available assays and benchmarked their applicability against each other. Herein, we compared the technology readiness level in the clinical context, economic aspects, implementation as part of routine point-of-care testing as well as performance power. Since the preventive care market is the most promising application sector, we also investigated whether the developments predominantly occur in the context of early disease detection or surveillance of therapy success. In addition, we provided a careful view on the current biotechnology investment activities in this sector to indicate the most attractive strategies for future economic success. Taken together, our review shall serve as a current reference, at the interplay of technology, clinical use and economic potential, to guide the interested readers in this rapid developing sector of precision medicine.

Language:English
Keywords:liquid biopsy, circulating free nucleic acids, exosome, cancer biomarker
Work type:Article
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2021
Number of pages:26 str.
Numbering:Vol. 13, iss. 20, art. 5060
PID:20.500.12556/RUL-136264 This link opens in a new window
UDC:616-006
ISSN on article:2072-6694
DOI:10.3390/cancers13205060 This link opens in a new window
COBISS.SI-ID:80452099 This link opens in a new window
Publication date in RUL:21.04.2022
Views:443
Downloads:85
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Record is a part of a journal

Title:Cancers
Shortened title:Cancers
Publisher:MDPI
ISSN:2072-6694
COBISS.SI-ID:517914137 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:10.10.2021

Secondary language

Language:Slovenian
Keywords:tekoča biopsija, proste nukleinske kisline v obtoku, eksosom

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P1-0390
Name:Funkcijska genomika in biotehnologija za zdravje

Funder:ARRS - Slovenian Research Agency
Project number:Z3-2649
Name:Določitev novih biomarkerjev glioblastoma za namen neinvazivne tekočinske biopsije

Funder:EC - European Commission
Funding programme:Interreg V-A Italia-Slovenija
Project number:146
Acronym:TRANS-GLIOMA

Funder:Other - Other funder or multiple funders
Funding programme:Bundesministerium für Bildung und Forschung
Project number:03VP03791/2

Funder:Other - Other funder or multiple funders
Funding programme:Bundesministerium für Bildung und Forschung
Project number:13GW0493B

Funder:Other - Other funder or multiple funders
Funding programme:Deutsche Forschungsgemeinschaft

Funder:Other - Other funder or multiple funders
Funding programme:Bundesministerium für Bildung und Forschung
Project number:404478562

Funder:Other - Other funder or multiple funders
Funding programme:Bundesministerium für Bildung und Forschung
Project number:421356369

Funder:Other - Other funder or multiple funders
Funding programme:Bundesministerium für Bildung und Forschung
Project number:446617142

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