Biocatalytic process intensification via efficient biocatalyst immobilization, miniaturization, and process integration
ID Žnidaršič Plazl, Polona (Author)

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Despite their sustainability, the potential of biocatalytic processes in industrial production is far from being realized. The main challenges in this field are the development of highly active, robust, and stable biocatalysts, the efficient regeneration of cofactors, and the prevention of biocatalyst deactivation under harsh industrial conditions. In addition to biocatalyst engineering, efficient enzyme and cell immobilization plays a crucial role in process feasibility. Reactor miniaturization, continuous operation, and integration with in situ product removal, process analytics, and cascade reactions that reduce the number of process steps enable process intensification. Mathematical model–based reactor and process design comprising time-scale analysis and efficient capacity increase can push the boundaries of biocatalytic processes toward industrial requirements. This review highlights the latest trends in efficient biocatalyst immobilization, miniaturization, and process integration to intensify biocatalytic processes.

Keywords:microreactor, continuous process, biocatalyst immobilization, reactor design, process intensification
Work type:Article (dk_c)
Typology:1.02 - Review Article
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Publication status in journal:Published
Article version:Publisher's version of article
Publication date:01.12.2021
Number of pages:Str. 1-8
Numbering:Vol. 32
PID:20.500.12556/RUL-136180 This link opens in a new window
ISSN on article:2452-2236
DOI:10.1016/j.cogsc.2021.100546 This link opens in a new window
COBISS.SI-ID:73824771 This link opens in a new window
Publication date in RUL:15.04.2022
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Record is a part of a journal

Title:Current opinion in green and sustainable chemistry
COBISS.SI-ID:528288537 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.12.2021

Secondary language

Keywords:mikroreaktorji, kontinuirni procesi, imobilizacija biokatalizatorjev, načrtovanje reaktorjev, intenzifikacija procesa


Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:P2-0191
Name:Kemijsko inženirstvo

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project number:J4-1775
Name:Razvoj mikropretočnih sistemov za analizo, izbor in uporabo bakterijskih celic

Funder:EC - European Commission
Funding programme:H2020
Project number:811040
Name:Chair Of Micro Process Engineering and TEchnology

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