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Biocatalytic process intensification via efficient biocatalyst immobilization, miniaturization, and process integration
ID
Žnidaršič Plazl, Polona
(
Author
)
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https://www.sciencedirect.com/science/article/pii/S2452223621001024
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Abstract
Despite their sustainability, the potential of biocatalytic processes in industrial production is far from being realized. The main challenges in this field are the development of highly active, robust, and stable biocatalysts, the efficient regeneration of cofactors, and the prevention of biocatalyst deactivation under harsh industrial conditions. In addition to biocatalyst engineering, efficient enzyme and cell immobilization plays a crucial role in process feasibility. Reactor miniaturization, continuous operation, and integration with in situ product removal, process analytics, and cascade reactions that reduce the number of process steps enable process intensification. Mathematical model–based reactor and process design comprising time-scale analysis and efficient capacity increase can push the boundaries of biocatalytic processes toward industrial requirements. This review highlights the latest trends in efficient biocatalyst immobilization, miniaturization, and process integration to intensify biocatalytic processes.
Language:
English
Keywords:
microreactor
,
continuous process
,
biocatalyst immobilization
,
reactor design
,
process intensification
Work type:
Article
Typology:
1.02 - Review Article
Organization:
FKKT - Faculty of Chemistry and Chemical Technology
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
8 str.
Numbering:
Vol. 32, art. 100546
PID:
20.500.12556/RUL-136180
UDC:
66.098
ISSN on article:
2452-2236
DOI:
10.1016/j.cogsc.2021.100546
COBISS.SI-ID:
73824771
Publication date in RUL:
15.04.2022
Views:
901
Downloads:
139
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Record is a part of a journal
Title:
Current opinion in green and sustainable chemistry
Publisher:
Elsevier
ISSN:
2452-2236
COBISS.SI-ID:
528288537
Licences
License:
CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:
http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:
The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Secondary language
Language:
Slovenian
Keywords:
mikroreaktorji
,
kontinuirni procesi
,
imobilizacija biokatalizatorjev
,
načrtovanje reaktorjev
,
intenzifikacija procesa
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P2-0191
Name:
Kemijsko inženirstvo
Funder:
ARRS - Slovenian Research Agency
Project number:
J4-1775
Name:
Razvoj mikropretočnih sistemov za analizo, izbor in uporabo bakterijskih celic
Funder:
EC - European Commission
Funding programme:
H2020
Project number:
811040
Name:
Chair Of Micro Process Engineering and TEchnology
Acronym:
COMPETE
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