STAT5 as a key protein of erythropoietin signalization

Tóthová, Zuzana (author), Tomc, Jana (author), Debeljak, Nataša (author), Solár, Peter (author)

Erythropoietin (EPO) acts on multiple tissues through its receptor EPOR, a member of a cytokine class I receptor superfamily with pleiotropic effects. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and MAPK. The canonical EPOR/JAK2/STAT5 pathway is a known regulator of differentiation, proliferation, and cell survival of erythroid progenitors. In addition, its role in the protection of other cells, including cancer cells, is under intense investigation. The involvement of EPOR/JAK2/STAT5 in other processes such as mRNA splicing, cytoskeleton reorganization, and cell metabolism has been recently described. The transcriptomics, proteomics, and epigenetic studies reviewed in this article provide a detailed understanding of EPO signalization. Advances in this area of research may be useful for improving the efficacy of EPO therapy in hematologic disorders, as well as in cancer treatment.

• Language: English
• Keywords: STAT5, erythropoietin receptor, molecular mechanisms, erythropoietin
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 13 str.
• Numbering: Vol. 22, iss. 13, art. 7109
• PID: 20.500.12556/RUL-135745
• UDC: 61
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms22137109
• COBISS.SI-ID: 70001667
• Publication date in RUL: 30.03.2022

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.07.2021

Secondary language

• Language: Slovenian
• Keywords: STAT5, eritropoetinski receptor, molekularni mehanizmi

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: Slovak Republic, Ministry of Education, Scientific Grant Agency
• Project number: VEGA1/0536/19