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STAT5 as a key protein of erythropoietin signalization
ID
Tóthová, Zuzana
(
Author
),
ID
Tomc, Jana
(
Author
),
ID
Debeljak, Nataša
(
Author
),
ID
Solár, Peter
(
Author
)
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MD5: B58D0131556D0478C594719EBEB69B69
URL - Source URL, Visit
https://www.mdpi.com/1422-0067/22/13/7109
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Abstract
Erythropoietin (EPO) acts on multiple tissues through its receptor EPOR, a member of a cytokine class I receptor superfamily with pleiotropic effects. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and MAPK. The canonical EPOR/JAK2/STAT5 pathway is a known regulator of differentiation, proliferation, and cell survival of erythroid progenitors. In addition, its role in the protection of other cells, including cancer cells, is under intense investigation. The involvement of EPOR/JAK2/STAT5 in other processes such as mRNA splicing, cytoskeleton reorganization, and cell metabolism has been recently described. The transcriptomics, proteomics, and epigenetic studies reviewed in this article provide a detailed understanding of EPO signalization. Advances in this area of research may be useful for improving the efficacy of EPO therapy in hematologic disorders, as well as in cancer treatment.
Language:
English
Keywords:
STAT5
,
erythropoietin receptor
,
molecular mechanisms
,
erythropoietin
Work type:
Article
Typology:
1.02 - Review Article
Organization:
MF - Faculty of Medicine
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
13 str.
Numbering:
Vol. 22, iss. 13, art. 7109
PID:
20.500.12556/RUL-135745
UDC:
61
ISSN on article:
1422-0067
DOI:
10.3390/ijms22137109
COBISS.SI-ID:
70001667
Publication date in RUL:
30.03.2022
Views:
1030
Downloads:
107
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Record is a part of a journal
Title:
International journal of molecular sciences
Shortened title:
Int. j. mol. sci.
Publisher:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.07.2021
Secondary language
Language:
Slovenian
Keywords:
STAT5
,
eritropoetinski receptor
,
molekularni mehanizmi
Projects
Funder:
Other - Other funder or multiple funders
Funding programme:
Slovak Republic, Ministry of Education, Scientific Grant Agency
Project number:
VEGA1/0536/19
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