STAT5 as a key protein of erythropoietin signalization

Tóthová, Zuzana (avtor), Tomc, Jana (avtor), Debeljak, Nataša (avtor), Solár, Peter (avtor)

Erythropoietin (EPO) acts on multiple tissues through its receptor EPOR, a member of a cytokine class I receptor superfamily with pleiotropic effects. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and MAPK. The canonical EPOR/JAK2/STAT5 pathway is a known regulator of differentiation, proliferation, and cell survival of erythroid progenitors. In addition, its role in the protection of other cells, including cancer cells, is under intense investigation. The involvement of EPOR/JAK2/STAT5 in other processes such as mRNA splicing, cytoskeleton reorganization, and cell metabolism has been recently described. The transcriptomics, proteomics, and epigenetic studies reviewed in this article provide a detailed understanding of EPO signalization. Advances in this area of research may be useful for improving the efficacy of EPO therapy in hematologic disorders, as well as in cancer treatment.

• Jezik: Angleški jezik
• Ključne besede: STAT5, erythropoietin receptor, molecular mechanisms, erythropoietin
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 13 str.
• Številčenje: Vol. 22, iss. 13, art. 7109
• PID: 20.500.12556/RUL-135745
• UDK: 61
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms22137109
• COBISS.SI-ID: 70001667
• Datum objave v RUL: 30.03.2022

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.07.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: STAT5, eritropoetinski receptor, molekularni mehanizmi

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: Slovak Republic, Ministry of Education, Scientific Grant Agency
• Številka projekta: VEGA1/0536/19