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Thermal (in)stability of atropine and scopolamine in the GC-MS inlet
ID
Koželj, Gordana
(
Avtor
),
ID
Prosen, Helena
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,00 MB)
MD5: B44B9802060B61EE0F2E3A6DF7F33666
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2305-6304/9/7/156
Galerija slik
Izvleček
The intoxication due to unintentional or intentional ingestion of plant material containing tropane alkaloids is quite frequent. GC-MS method is still widely used for the identification of these toxicologically important substances in human specimen. During general unknown analysis, high temperature of inlet, at least 270 °C, is commonly used for less volatile substances. Unfortunately, both tropanes are thermally unstable and could be overlooked due to their degradation. The temperaturerelated degradation of tropanes atropine and scopolamine was systematically studied in the inlet of a GC-MS instrument in the range 110–250 °C by increments of 20 °C, additionally also at 275 °C, and in different solvents. At inlet temperatures not higher than 250 °C, the degradation products were formed by elimination of water and cleavage of atropine’s ester bond. At higher temperatures, elimination of formaldehyde became predominant. These phenomena were less pronounced when ethyl acetate was used instead of methanol, while n-hexane proved unsuitable for several reasons. At an inlet temperature of 275 °C, tropanes were barely detectable. During systematic toxicological analysis, any tropanes’ degradation products should indicate the possible presence of atropine and/or scopolamine in the sample. It is not necessary to prepare thermally stable derivatives for confirmation. Instead, the inlet temperature can be decreased to 250 °C, which diminishes their degradation to a level where their detection and identification are possible. This was demonstrated in several case studies.
Jezik:
Angleški jezik
Ključne besede:
atropine
,
scopolamine
,
thermal stability
,
GC-MS inlet
,
degradation
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
11 str.
Številčenje:
Vol. 9, iss. 7, art. 156
PID:
20.500.12556/RUL-135733
UDK:
543.544.3:543.51:547.9
ISSN pri članku:
2305-6304
DOI:
10.3390/toxics9070156
COBISS.SI-ID:
69304323
Datum objave v RUL:
30.03.2022
Število ogledov:
1304
Število prenosov:
117
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Objavi na:
Gradivo je del revije
Naslov:
Toxics : Elektronski vir
Skrajšan naslov:
Toxics
Založnik:
MDPI
ISSN:
2305-6304
COBISS.SI-ID:
520262681
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.07.2021
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
atropin
,
skopolamin
,
toplotna stabilnost
,
injektor GC-MS
,
razgradnja
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0153
Naslov:
Raziskave in razvoj analiznih metod in postopkov
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