The role of PI3K/AKT and MAPK signaling pathways in erythropoietin signalization

Tóthová, Zuzana (author), Šemeláková, Martina (author), Solárová, Zuzana (author), Tomc, Jana (author), Debeljak, Nataša (author), Solár, Peter (author)

Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on varioustypes of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5,MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, wedescribe the role of the MAPK and PI3K/AKT signaling pathways during red blood cell formationas well as in non-hematopoietic tissues and tumor cells. Although the central framework of thesepathways is similar for most of cell types, there are some stage-specific, tissue, and cell-lineagedifferences. We summarize the current state of research in this field, highlight the novel members ofEPO-induced PI3K and MAPK signaling, and in this respect also the differences between erythroidand non-erythroid cells.

• Language: English
• Keywords: erythropoietin, PI3K, MAPK
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 14 str.
• Numbering: Vol. 22, iss. 14, art. 7682
• PID: 20.500.12556/RUL-135709
• UDC: 616.1
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms22147682
• COBISS.SI-ID: 71385603
• Publication date in RUL: 29.03.2022

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 19.07.2021

Secondary language

• Language: Slovenian
• Keywords: eritropoetin, PI3K, MAPK

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: Slovak Republic, Ministry of Education, Scientific Grant Agency
• Project number: VEGA1/0536/19