The role of PI3K/AKT and MAPK signaling pathways in erythropoietin signalization

Tóthová, Zuzana (avtor), Šemeláková, Martina (avtor), Solárová, Zuzana (avtor), Tomc, Jana (avtor), Debeljak, Nataša (avtor), Solár, Peter (avtor)

Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on varioustypes of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5,MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, wedescribe the role of the MAPK and PI3K/AKT signaling pathways during red blood cell formationas well as in non-hematopoietic tissues and tumor cells. Although the central framework of thesepathways is similar for most of cell types, there are some stage-specific, tissue, and cell-lineagedifferences. We summarize the current state of research in this field, highlight the novel members ofEPO-induced PI3K and MAPK signaling, and in this respect also the differences between erythroidand non-erythroid cells.

• Jezik: Angleški jezik
• Ključne besede: erythropoietin, PI3K, MAPK
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 14 str.
• Številčenje: Vol. 22, iss. 14, art. 7682
• PID: 20.500.12556/RUL-135709
• UDK: 616.1
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms22147682
• COBISS.SI-ID: 71385603
• Datum objave v RUL: 29.03.2022

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 19.07.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: eritropoetin, PI3K, MAPK

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: Slovak Republic, Ministry of Education, Scientific Grant Agency
• Številka projekta: VEGA1/0536/19