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Quality control of vitamins A and E and coenzyme Q10 in commercial anti-ageing cosmetic products
ID
Temova Rakuša, Žane
(
Author
),
ID
Roškar, Robert
(
Author
)
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https://www.mdpi.com/2079-9284/8/3/61
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Abstract
Vitamins A and E and coenzyme Q10 are common ingredients in anti-ageing cosmetic products. Within this study, we evaluated the quality of commercial cosmetics with vitamin A (35 products), vitamin E (49 products), and coenzyme Q10 (27 products) by using validated HPLC– UV methods. Vitamin A was determined as retinol, retinyl palmitate, retinyl propionate, β carotene, and hydroxypinacolone retinoate in concentrations ranging from 950 ng/g to 19 mg/g. Total vitamin A contents, expressed with retinol equivalents, ranged from 160 ng/g to 19 mg/g, and were above the maximum concentration recommended by the SCCS in six of the 35 tested cosmetics. The content-related quality control of 10 cosmetics with specified vitamin A content revealed significant deviations (between 0% and 400%) of the label claim. Vitamin E was determined as both tocopherol and tocopheryl acetate in concentrations between 8.5 µg/g and 16 mg/g. Coenzyme Q10 was determined as ubiquinone in 24 tested cosmetics, which labelled it, in concentrations between 4.2 µg/g and 100 µg/g. Labelling irregularities were observed in all three active compound groups, resulting in a significant share (42%) of improperly labelled cosmetic products. The results of this study reveal the need for stricter cosmetics regulation and highlight the importance of their quality control, especially by evaluating the contents of the active compounds, in their efficacy and safety assurance.
Language:
English
Keywords:
active compounds
,
assay
,
cosmeceutics
,
functional cosmetics
,
HPLC-UV
,
labelling
,
retinoids
,
tocopherol
,
ubiquinone
,
β carotene
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
17 str.
Numbering:
Vol. 8, iss. 3, art. 61
PID:
20.500.12556/RUL-135617
UDC:
577.161.6:665.58
ISSN on article:
2079-9284
DOI:
10.3390/cosmetics8030061
COBISS.SI-ID:
83392003
Publication date in RUL:
22.03.2022
Views:
1214
Downloads:
106
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Record is a part of a journal
Title:
Cosmetics
Shortened title:
Cosmetics
Publisher:
MDPI
ISSN:
2079-9284
COBISS.SI-ID:
523046937
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
01.09.2021
Secondary language
Language:
Slovenian
Keywords:
aktivne spojine
,
testi
,
funkcionalna kozmetika
,
označevanje
,
tokoferol
,
retinoidi
,
vitamin A
,
vitamin E
,
beta karoten
,
kozmetični izdelki
,
ubikinon
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0189
Name:
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih
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