Quality control of vitamins A and E and coenzyme Q10 in commercial anti-ageing cosmetic products

Temova Rakuša, Žane (avtor), Roškar, Robert (avtor)

Vitamins A and E and coenzyme Q10 are common ingredients in anti-ageing cosmetic products. Within this study, we evaluated the quality of commercial cosmetics with vitamin A (35 products), vitamin E (49 products), and coenzyme Q10 (27 products) by using validated HPLC– UV methods. Vitamin A was determined as retinol, retinyl palmitate, retinyl propionate, β carotene, and hydroxypinacolone retinoate in concentrations ranging from 950 ng/g to 19 mg/g. Total vitamin A contents, expressed with retinol equivalents, ranged from 160 ng/g to 19 mg/g, and were above the maximum concentration recommended by the SCCS in six of the 35 tested cosmetics. The content-related quality control of 10 cosmetics with specified vitamin A content revealed significant deviations (between 0% and 400%) of the label claim. Vitamin E was determined as both tocopherol and tocopheryl acetate in concentrations between 8.5 µg/g and 16 mg/g. Coenzyme Q10 was determined as ubiquinone in 24 tested cosmetics, which labelled it, in concentrations between 4.2 µg/g and 100 µg/g. Labelling irregularities were observed in all three active compound groups, resulting in a significant share (42%) of improperly labelled cosmetic products. The results of this study reveal the need for stricter cosmetics regulation and highlight the importance of their quality control, especially by evaluating the contents of the active compounds, in their efficacy and safety assurance.

• Jezik: Angleški jezik
• Ključne besede: active compounds, assay, cosmeceutics, functional cosmetics, HPLC-UV, labelling, retinoids, tocopherol, ubiquinone, β carotene
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 17 str.
• Številčenje: Vol. 8, iss. 3, art. 61
• PID: 20.500.12556/RUL-135617
• UDK: 577.161.6:665.58
• ISSN pri članku: 2079-9284
• DOI: 10.3390/cosmetics8030061
• COBISS.SI-ID: 83392003
• Datum objave v RUL: 22.03.2022

Gradivo je del revije

• Naslov: Cosmetics
• Skrajšan naslov: Cosmetics
• Založnik: MDPI
• ISSN: 2079-9284
• COBISS.SI-ID: 523046937

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.09.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: aktivne spojine, testi, funkcionalna kozmetika, označevanje, tokoferol, retinoidi, vitamin A, vitamin E, beta karoten, kozmetični izdelki, ubikinon

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0189
• Naslov: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih