Your browser does not allow JavaScript!
JavaScript is necessary for the proper functioning of this website. Please enable JavaScript or use a modern browser.
Open Science Slovenia
Open Science
DiKUL
slv
|
eng
Search
Browse
New in RUL
About RUL
In numbers
Help
Sign in
High-frequency and high-voltage asymmetric bipolar pulse generator for electroporation based technologies and therapies
ID
Pirc, Eva
(
Author
),
ID
Miklavčič, Damijan
(
Author
),
ID
Uršič Valentinuzzi, Katja
(
Author
),
ID
Serša, Gregor
(
Author
),
ID
Reberšek, Matej
(
Author
)
PDF - Presentation file,
Download
(5,38 MB)
MD5: 9000A6E9026E7E48A92726F373BF92B8
URL - Source URL, Visit
https://www.mdpi.com/2079-9292/10/10/1203
Image galllery
Abstract
Currently, in high-frequency electroporation, much progress has been made but limited to research groups with custom-made laboratory prototype electroporators. According to the review of electroporators and economic evaluations, there is still an area of pulse parameters that needs to be investigated. The development of an asymmetric bipolar pulse generator with a maximum voltage of 4 kV and minimum duration time of a few hundred nanoseconds, would enable in vivo evaluation of biological effects of high-frequency electroporation pulses. Herein, from a series of most commonly used drivers and optical isolations in high-voltage pulse generators the one with optimal characteristics was used. In addition, the circuit topology of the developed device is described in detail. The developed device is able to generate 4 kV pulses, with theoretical 131 A maximal current and 200 ns minimal pulse duration, the maximal pulse repetition rate is 2 MHz and the burst maximal repetition rate is 1 MHz. The device was tested in vivo. The effectiveness of electrochemotherapy of high-frequency electroporation pulses is compared to “classical” electrochemotherapy pulses. In vivo electrochemotherapy with high-frequency electroporation pulses was at least as effective as with “classical” well-established electric pulses, resulting in 86% and 50% complete responses, respectively. In contrast to previous reports, however, muscle contractions were comparable between the two protocols.
Language:
English
Keywords:
electroporation
,
electroporation device
,
high-frequency
,
bipolar
,
asymmetric
,
SiC MOSFET
,
high-voltage
,
pulse generator
,
electrochemotherapy
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FE - Faculty of Electrical Engineering
ZF - Faculty of Health Sciences
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
19 str.
Numbering:
Vol. 10, iss. 10, art. 1203
PID:
20.500.12556/RUL-135440
UDC:
602.621:621.3
ISSN on article:
2079-9292
DOI:
10.3390/electronics10101203
COBISS.SI-ID:
63928323
Publication date in RUL:
15.03.2022
Views:
834
Downloads:
106
Metadata:
Cite this work
Plain text
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Copy citation
Share:
Record is a part of a journal
Title:
Electronics
Shortened title:
Electronics
Publisher:
MDPI
ISSN:
2079-9292
COBISS.SI-ID:
523068953
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
18.05.2021
Secondary language
Language:
Slovenian
Keywords:
elektroporacija
,
naprava za elektroporacijo
,
visoka frekvenca
,
bipolarni
,
asimetrični
,
SiC MOSFET
,
visoka napetost
,
pulzni generatorji
,
elektrokemoterapija
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
I0-0022
Name:
Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)
Funder:
ARRS - Slovenian Research Agency
Project number:
P2-0249
Name:
Elektroporacija v biologiji, biotehnologiji in medicini
Funder:
ARRS - Slovenian Research Agency
Project number:
P3-0003
Name:
Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev
Funder:
ARRS - Slovenian Research Agency
Project number:
J2-9227
Name:
Elektroporacijske terapije z novimi visokofrekvenčnimi elektroporacijskimi pulzi
Funder:
ARRS - Slovenian Research Agency
Funding programme:
Junior Researchers
Similar documents
Similar works from RUL:
Similar works from other Slovenian collections:
Back