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Supplementation with >Your< Iron Syrup corrects iron status in a mouse model of diet-induced iron deficiency
ID Pirman, Tatjana (Author), ID Lenardič, Ajda (Author), ID Nemec Svete, Alenka (Author), ID Horvat, Simon (Author)

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Abstract
The objective of this study was to compare the effects of >Your< Iron Syrup, a novel oral liquid iron-containing food supplement, with the commonly prescribed iron sulphate (Fe-sulphate) in a mouse model of diet-induced iron deficiency. Standard inbred BALB/cOlaHsd mice were fed low-iron diet for 11 weeks to induce significant decrease in blood haemoglobin and haematocrit and were then supplemented by gavage with either >Your< Iron Syrup or Fe-sulphate for two weeks. In >Your< Iron Syrup group, several markers of iron deficiency, such as serum iron concentration, transferrin saturation and ferritin level were significantly improved in both female and male mice. Fe-sulphate induced similar responses, except that it did not significantly increase iron serum in females and serum ferritin in both sexes. Fe-sulphate significantly increased liver-iron content which >Your< Iron Syrup did not. Transcription of Hamp and selected inflammatory genes in the liver was comparable between the two supplementation groups and with the Control diet group. Some sex-specific effects were noted, which were more pronounced and less variable in males. In conclusion, >Your< Iron Syrup was efficient, comparable and in some parameters superior to Fe-sulphate in improving iron-related parameters without inducing a response of selected liver inflammation markers in a mouse model of diet-induced iron deficiency.

Language:English
Keywords:nutritional iron deficiency, oral supplementation, mice, >Your< Iron Syrup, Fe-sulphate
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:BF - Biotechnical Faculty
VF - Veterinary Faculty
Publication status:Published
Publication version:Version of Record
Year:2021
Number of pages:19 str.
Numbering:Vol. 10, iss. 5, art. 357
PID:20.500.12556/RUL-135325 This link opens in a new window
UDC:612
ISSN on article:2079-7737
DOI:10.3390/biology10050357 This link opens in a new window
COBISS.SI-ID:61018627 This link opens in a new window
Publication date in RUL:08.03.2022
Views:1861
Downloads:109
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Record is a part of a journal

Title:Biology
Shortened title:Biology
Publisher:MDPI
ISSN:2079-7737
COBISS.SI-ID:523004441 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.05.2021

Secondary language

Language:Slovenian
Keywords:pomanjkanje železa, železo, prehranski dodatki, laboratorijske miši

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P4-0220
Name:Primerjalna genomika in genomska biodiverziteta

Funder:ARRS - Slovenian Research Agency
Project number:P4-0097
Name:Prehrana in mikrobna ekologija prebavil

Funder:Other - Other funder or multiple funders
Funding programme:PharmaLinea Ltd.

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