Supplementation with >Your< Iron Syrup corrects iron status in a mouse model of diet-induced iron deficiency

Pirman, Tatjana (author), Lenardič, Ajda (author), Nemec Svete, Alenka (author), Horvat, Simon (author)

The objective of this study was to compare the effects of >Your< Iron Syrup, a novel oral liquid iron-containing food supplement, with the commonly prescribed iron sulphate (Fe-sulphate) in a mouse model of diet-induced iron deficiency. Standard inbred BALB/cOlaHsd mice were fed low-iron diet for 11 weeks to induce significant decrease in blood haemoglobin and haematocrit and were then supplemented by gavage with either >Your< Iron Syrup or Fe-sulphate for two weeks. In >Your< Iron Syrup group, several markers of iron deficiency, such as serum iron concentration, transferrin saturation and ferritin level were significantly improved in both female and male mice. Fe-sulphate induced similar responses, except that it did not significantly increase iron serum in females and serum ferritin in both sexes. Fe-sulphate significantly increased liver-iron content which >Your< Iron Syrup did not. Transcription of Hamp and selected inflammatory genes in the liver was comparable between the two supplementation groups and with the Control diet group. Some sex-specific effects were noted, which were more pronounced and less variable in males. In conclusion, >Your< Iron Syrup was efficient, comparable and in some parameters superior to Fe-sulphate in improving iron-related parameters without inducing a response of selected liver inflammation markers in a mouse model of diet-induced iron deficiency.

• Language: English
• Keywords: nutritional iron deficiency, oral supplementation, mice, >Your< Iron Syrup, Fe-sulphate
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: BF - Biotechnical Faculty; VF - Veterinary Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 19 str.
• Numbering: Vol. 10, iss. 5, art. 357
• PID: 20.500.12556/RUL-135325
• UDC: 612
• ISSN on article: 2079-7737
• DOI: 10.3390/biology10050357
• COBISS.SI-ID: 61018627
• Publication date in RUL: 08.03.2022

Record is a part of a journal

• Title: Biology
• Shortened title: Biology
• Publisher: MDPI
• ISSN: 2079-7737
• COBISS.SI-ID: 523004441

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.05.2021

Secondary language

• Language: Slovenian
• Keywords: pomanjkanje železa, železo, prehranski dodatki, laboratorijske miši