20.500.12556/RUL-135325 Supplementation with >Your< Iron Syrup corrects iron status in a mouse model of diet-induced iron deficiency The objective of this study was to compare the effects of >Your< Iron Syrup, a novel oral liquid iron-containing food supplement, with the commonly prescribed iron sulphate (Fe-sulphate) in a mouse model of diet-induced iron deficiency. Standard inbred BALB/cOlaHsd mice were fed low-iron diet for 11 weeks to induce significant decrease in blood haemoglobin and haematocrit and were then supplemented by gavage with either >Your< Iron Syrup or Fe-sulphate for two weeks. In >Your< Iron Syrup group, several markers of iron deficiency, such as serum iron concentration, transferrin saturation and ferritin level were significantly improved in both female and male mice. Fe-sulphate induced similar responses, except that it did not significantly increase iron serum in females and serum ferritin in both sexes. Fe-sulphate significantly increased liver-iron content which >Your< Iron Syrup did not. Transcription of Hamp and selected inflammatory genes in the liver was comparable between the two supplementation groups and with the Control diet group. Some sex-specific effects were noted, which were more pronounced and less variable in males. In conclusion, >Your< Iron Syrup was efficient, comparable and in some parameters superior to Fe-sulphate in improving iron-related parameters without inducing a response of selected liver inflammation markers in a mouse model of diet-induced iron deficiency. nutritional iron deficiency oral supplementation mice >Your< Iron Syrup Fe-sulphate pomanjkanje železa železo prehranski dodatki laboratorijske miši true false true Angleški jezik Slovenski jezik Članek v reviji 2022-03-08 09:03:17 2022-03-08 09:03:17 2022-09-14 04:12:47 0000-00-00 00:00:00 2021 0 0 19 str. iss. 5, art. 357 Vol. 10 Apr. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 612 2079-7737 10.3390/biology10050357 61018627 RAZ_Pirman_Tatjana_2021.pdf RAZ_Pirman_Tatjana_2021.pdf 1 CD6AD3A063E045EAEE3C540B6213F79F 42a8a67f7e1d09f62523ff9249fa608f2f4c225bfabe863883e5e24481cc6053 4e129cd4-9eb6-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154333 https://www.mdpi.com/2079-7737/10/5/357 1 ef4c03a0-9eb5-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=154332 Biotehniška fakulteta Veterinarska fakulteta 0 0 0