Microwave-assisted multicomponent syntheses of heterocyclic phosphonates

Bálint, Erika (author), Popovics-Tóth, Nóra (author), Tajti, Ádám (author), Rávai, Bettina (author), Szabó, Kármen Emőke (author), Perdih, Franc (author)

Organophosphorus compounds play an important role in the medicinal- or agricultural industry, and in the human body as well. Over the last years, heterocyclic phosphonates have received growing interest due to their potential biological activity. An efficient tool for the preparation of such derivatives is their synthesis via multicomponent reactions. These transformations possess several criteria of an “ideal synthesis”, such as high atom economy, fast and simple accomplishment, energy efficiency, and environmentally friendliness. A number of heterocyclic phosphonates were prepared by us utilizing multicomponent syntheses. In this proceeding, the synthesis of the diethyl (2-amino-3-cyano-4H-chromen-4-yl)phosphonate by the condensation of salicylaldehyde, malononitrile and diethyl phosphite is briefly introduced. The reaction was optimized in respect of the catalyst type, the catalyst amount, the reaction time, and the temperature.

• Language: English
• Keywords: microwave, three-component reaction, multicomponent synthesis, (4H-chromen-4-yl)phosphonate
• Work type: Article
• Typology: 1.08 - Published Scientific Conference Contribution
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 5 str.
• Numbering: Vol. 3, iss. 1, art. 108
• PID: 20.500.12556/RUL-135321
• UDC: 547.7/.8
• ISSN on article: 2673-4583
• DOI: 10.3390/ecsoc-24-08548
• COBISS.SI-ID: 64358915
• Publication date in RUL: 08.03.2022

Record is a part of a journal

• Title: Chemistry proceedings
• Shortened title: Chem. proc.
• Publisher: MDPI
• ISSN: 2673-4583
• COBISS.SI-ID: 64314883

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.01.2021

Secondary language

• Language: Slovenian
• Keywords: mikrovalovi, trikomponentne reakcije, večkomponentna sinteza