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Validated stability-indicating GC-MS method for characterization of forced degradation products of trans-caffeic acid and trans-ferulic acid
ID
Islamčević Razboršek, Maša
(
Avtor
),
ID
Ivanović, Milena
(
Avtor
),
ID
Kolar, Mitja
(
Avtor
)
PDF - Predstavitvena datoteka,
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(896,29 KB)
MD5: A513AF7874E82C1AFEA12621833EBFE7
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/1420-3049/26/9/2475
Galerija slik
Izvleček
When dealing with simple phenols such as caffeic acid (CA) and ferulic acid (FA), found in a variety of plants, it is very important to have control over the most important factors that accelerate their degradation reactions. This is the first report in which the stabilities of these two compounds have been systematically tested by exposure to various different factors. Forced degradation studies were performed on pure standards (trans-CA and trans-FA), dissolved in different solvents and exposed to different oxidative, photolytic and thermal stress conditions. Additionally, a rapid, sensitive, and selective stability-indicating gas chromatographic-mass spectrometric method was developed and validated for determination of trans-CA and trans-FA in the presence of their degradation products. Cis-CA and cis-FA were confirmed as the only degradation products in all the experiments performed. All the compounds were perfectly separated by gas chromatography (GC) and identified using mass spectrometry (MS), a method that additionally elucidated their structures. In general, more protic solvents, higher temperatures, UV radiation and longer storage times led to more significant degradation (isomerization) of both trans-isomers. The most progressive isomerization of both compounds (up to 43%) was observed when the polar solutions were exposed to daylight at room temperature for 1 month. The method was validated for linearity, precision as repeatability, limit of detection (LOD) and limit of quantitation (LOQ). The method was confirmed as linear over tested concentration ranges from 1−100 mg L$^{−1}$ (r$^2$s were above 0.999). The LOD and LOQ for trans-FA were 0.15 mg L$^{−1}$ and 0.50 mg L$^{−1}$, respectively. The LOD and LOQ for trans-CA were 0.23 mg L$^{−1}$ and 0.77 mg L$^{−1}$, respectively.
Jezik:
Angleški jezik
Ključne besede:
caffeic acid
,
ferulic acid
,
stability studies
,
GC-MS
,
forced degradation
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
12 str.
Številčenje:
Vol. 26, iss. 9, art. 2475
PID:
20.500.12556/RUL-135298
UDK:
66
ISSN pri članku:
1420-3049
DOI:
10.3390/molecules26092475
COBISS.SI-ID:
61605891
Datum objave v RUL:
07.03.2022
Število ogledov:
550
Število prenosov:
104
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Objavi na:
Gradivo je del revije
Naslov:
Molecules
Skrajšan naslov:
Molecules
Založnik:
MDPI
ISSN:
1420-3049
COBISS.SI-ID:
18462981
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.05.2021
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
kofeinska kislina
,
prisilna degradacija
,
študija stabilnosti
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P2-0006
Naslov:
Fizikalno kemijski pojavi na površinskih plasteh in uporaba nanodelcev
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P1-0153
Naslov:
Raziskave in razvoj analiznih metod in postopkov
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