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Polynuclear silver(I) complex with thianthrene : structural characterization, antimicrobial activity and interaction with biomolecules
ID Ašanin, Darko P. (Author), ID Andrejević, Tina P. (Author), ID Skaro-Bogojevic, Sanja (Author), ID Stevanović, Nevena Lj. (Author), ID Aleksić, Ivana (Author), ID Milivojević, Dušan (Author), ID Perdih, Franc (Author), ID Turel, Iztok (Author), ID Djuran, Miloš I. (Author), ID Glišić, Biljana Đ. (Author)

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Abstract
New silver(I) complex with thianthrene (tia), [Ag(NO$_3$)(tia)(H$_2$O)]$_n$, was synthesized by the reaction of AgNO$_3$ with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO$_3$)(tia)(H$_2$O)]$_n$ with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids.

Language:English
Keywords:silver(I) complexes, thianthrene, antimicrobial activity, DNA/BSA interaction
Work type:Article
Typology:1.08 - Published Scientific Conference Contribution
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Publication status:Published
Publication version:Version of Record
Year:2020
Number of pages:7 str.
Numbering:Vol. 67, iss. 1, art. 4
PID:20.500.12556/RUL-134980 This link opens in a new window
UDC:546.57
ISSN on article:2504-3900
DOI:10.3390/ASEC2020-07534 This link opens in a new window
COBISS.SI-ID:44168195 This link opens in a new window
Publication date in RUL:16.02.2022
Views:966
Downloads:136
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Record is a part of a journal

Title:Proceedings
Shortened title:Proceedings
Publisher:MDPI
ISSN:2504-3900
COBISS.SI-ID:42487341 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:30.11.2020

Secondary language

Language:Slovenian
Keywords:srebro, srebrovi kompleksi, protimikrobno delovanje, interakcije z biomolekulami

Projects

Funder:MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Project number:451-03-68/2020-14/200042

Funder:MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Project number:451-03-68/2020-14/200122

Funder:MESTD - Ministry of Education, Science and Technological Development of Republic of Serbia
Project number:451-03-68/2020-14/200378

Funder:ARRS - Slovenian Research Agency
Project number:P1-0175
Name:Napredna anorganska kemija

Funder:Other - Other funder or multiple funders
Funding programme:Serbian Academy of Sciences and Arts
Project number:01-2019-F65

Funder:Other - Other funder or multiple funders
Funding programme:Serbian Academy of Sciences and Arts
Project number:F128

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