Polynuclear silver(I) complex with thianthrene : structural characterization, antimicrobial activity and interaction with biomolecules

Ašanin, Darko P. (author), Andrejević, Tina P. (author), Skaro-Bogojevic, Sanja (author), Stevanović, Nevena Lj. (author), Aleksić, Ivana (author), Milivojević, Dušan (author), Perdih, Franc (author), Turel, Iztok (author), Djuran, Miloš I. (author), Glišić, Biljana Đ. (author)

New silver(I) complex with thianthrene (tia), [Ag(NO$_3$)(tia)(H$_2$O)]$_n$, was synthesized by the reaction of AgNO$_3$ with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO$_3$)(tia)(H$_2$O)]$_n$ with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids.

• Language: English
• Keywords: silver(I) complexes, thianthrene, antimicrobial activity, DNA/BSA interaction
• Work type: Article
• Typology: 1.08 - Published Scientific Conference Contribution
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 7 str.
• Numbering: Vol. 67, iss. 1, art. 4
• PID: 20.500.12556/RUL-134980
• UDC: 546.57
• ISSN on article: 2504-3900
• DOI: 10.3390/ASEC2020-07534
• COBISS.SI-ID: 44168195
• Publication date in RUL: 16.02.2022

Record is a part of a journal

• Title: Proceedings
• Shortened title: Proceedings
• Publisher: MDPI
• ISSN: 2504-3900
• COBISS.SI-ID: 42487341

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 30.11.2020

Secondary language

• Language: Slovenian
• Keywords: srebro, srebrovi kompleksi, protimikrobno delovanje, interakcije z biomolekulami