20.500.12556/RUL-134980 Polynuclear silver(I) complex with thianthrene structural characterization, antimicrobial activity and interaction with biomolecules New silver(I) complex with thianthrene (tia), [Ag(NO$_3$)(tia)(H$_2$O)]$_n$, was synthesized by the reaction of AgNO$_3$ with an equimolar amount of tia in ethanol/dichloromethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO$_3$)(tia)(H$_2$O)]$_n$ with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids. silver(I) complexes thianthrene antimicrobial activity DNA/BSA interaction srebro srebrovi kompleksi protimikrobno delovanje interakcije z biomolekulami true false true Angleški jezik Slovenski jezik Članek v reviji 2022-02-16 09:05:39 2022-02-16 09:05:39 2022-09-14 04:10:59 0000-00-00 00:00:00 2020 0 0 7 str. iss. 1, art. 4 Vol. 67 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 546.57 2504-3900 10.3390/ASEC2020-07534 44168195 RAZ_Asanin_Darko_P._2020.pdf RAZ_Asanin_Darko_P._2020.pdf 1 1062FE96450698BF9E6FD978A760326B 8a0e9f5c92dda5ba95e92ef88739159f289440e75a3a4901aca417503cee7031 d5fc5612-8f00-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153779 https://www.mdpi.com/2504-3900/67/1/4 0 3c9d8d9a-8f00-11ec-abdb-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=153777 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0