Vaccinomics and adversomics in the era of precision medicine : a review based on HBV, MMR, HPV, and COVID-19 vaccines

Omersel, Jasna (author), Karas Kuželički, Nataša (author)

Precision medicine approaches based on pharmacogenomics are now being successfully implemented to enable physicians to predict more efficient treatments and prevention strategies for a given disease based on the genetic background of the patient. This approach has already been proposed for vaccines, but research is lagging behind the needs of society, and precision medicine is far from being implemented here. While vaccinomics concerns the effectiveness of vaccines, adversomics concerns their side effects. This area has great potential to address public concerns about vaccine safety and to promote increased public confidence, higher vaccination rates, and fewer serious adverse events in genetically predisposed individuals. The aim here is to explore the contemporary scientific literature related to the vaccinomic and adversomic aspects of the three most-controversial vaccines: those against hepatitis B, against measles, mumps, and rubella, and against human Papilloma virus. We provide detailed information on the genes that encode human leukocyte antigen, cytokines and their receptors, and transcription factors and regulators associated with the efficacy and safety of the Hepatitis B and Measles, Mumps and Rubella virus vaccines. We also investigate the future prospects of vaccinomics and adversomics of a COVID-19 vaccine, which might represent the fastest development of a vaccine ever.

• Language: English
• Keywords: adversomics, COVID-19, genetics, hepatitis B, human Papilloma virus, MMR vaccine, precision medicine, vaccinomics
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 22 str.
• Numbering: Vol. 9, iss. 11, art. 3561
• PID: 20.500.12556/RUL-134726
• UDC: 615.015:575.111
• ISSN on article: 2077-0383
• DOI: 10.3390/jcm9113561
• COBISS.SI-ID: 35836931
• Publication date in RUL: 27.01.2022

Record is a part of a journal

• Title: Journal of clinical medicine
• Shortened title: J. clin. med.
• Publisher: MDPI
• ISSN: 2077-0383
• COBISS.SI-ID: 5405759

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 05.11.2020

Secondary language

• Language: Slovenian
• Keywords: genomika, farmakogenomika, cepiva, stranski učinki, humani papilomavirus, hepatitis B