Vaccinomics and adversomics in the era of precision medicine : a review based on HBV, MMR, HPV, and COVID-19 vaccines

Omersel, Jasna (avtor), Karas Kuželički, Nataša (avtor)

Precision medicine approaches based on pharmacogenomics are now being successfully implemented to enable physicians to predict more efficient treatments and prevention strategies for a given disease based on the genetic background of the patient. This approach has already been proposed for vaccines, but research is lagging behind the needs of society, and precision medicine is far from being implemented here. While vaccinomics concerns the effectiveness of vaccines, adversomics concerns their side effects. This area has great potential to address public concerns about vaccine safety and to promote increased public confidence, higher vaccination rates, and fewer serious adverse events in genetically predisposed individuals. The aim here is to explore the contemporary scientific literature related to the vaccinomic and adversomic aspects of the three most-controversial vaccines: those against hepatitis B, against measles, mumps, and rubella, and against human Papilloma virus. We provide detailed information on the genes that encode human leukocyte antigen, cytokines and their receptors, and transcription factors and regulators associated with the efficacy and safety of the Hepatitis B and Measles, Mumps and Rubella virus vaccines. We also investigate the future prospects of vaccinomics and adversomics of a COVID-19 vaccine, which might represent the fastest development of a vaccine ever.

• Jezik: Angleški jezik
• Ključne besede: adversomics, COVID-19, genetics, hepatitis B, human Papilloma virus, MMR vaccine, precision medicine, vaccinomics
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 22 str.
• Številčenje: Vol. 9, iss. 11, art. 3561
• PID: 20.500.12556/RUL-134726
• UDK: 615.015:575.111
• ISSN pri članku: 2077-0383
• DOI: 10.3390/jcm9113561
• COBISS.SI-ID: 35836931
• Datum objave v RUL: 27.01.2022

Gradivo je del revije

• Naslov: Journal of clinical medicine
• Skrajšan naslov: J. clin. med.
• Založnik: MDPI
• ISSN: 2077-0383
• COBISS.SI-ID: 5405759

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 05.11.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: genomika, farmakogenomika, cepiva, stranski učinki, humani papilomavirus, hepatitis B