Natural and synthetic derivatives of hydroxycinnamic acid modulating the pathological transformation of amyloidogenic proteins
ID Muronetz, Vladimir I. (Author), ID Barinova, Kseniya (Author), ID Kudryavtseva, Sofia (Author), ID Medvedeva, Maria (Author), ID Melnikova, Aleksandra (Author), ID Sevostyanova, Irina (Author), ID Semenyuk, Pavel (Author), ID Stroylova, Yulia (Author), ID Sova, Matej (Author)

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This review presents the main properties of hydroxycinnamic acid (HCA) derivatives and their potential application as agents for the prevention and treatment of neurodegenerative diseases. It is partially focused on the successful use of these compounds as inhibitors of amyloidogenic transformation of proteins. Firstly, the prerequisites for the emergence of interest in HCA derivatives, including natural compounds, are described. A separate section is devoted to synthesis and properties of HCA derivatives. Then, the results of molecular modeling of HCA derivatives with prion protein as well as with α-synuclein fibrils are summarized, followed by detailed analysis of the experiments on the effect of natural and synthetic HCA derivatives, as well as structurally similar phenylacetic and benzoic acid derivatives, on the pathological transformation of prion protein and α-synuclein. The ability of HCA derivatives to prevent amyloid transformation of some amyloidogenic proteins, and their presence not only in food products but also as natural metabolites in human blood and tissues, makes them promising for the prevention and treatment of neurodegenerative diseases of amyloid nature.

Keywords:neurodegenerative diseases, curcumin, derivatives of hydroxycinnamic acid, amyloid, α-synuclein, prion protein, amyloid fibrils, prevention of amyloid transformation, Parkinson's disease
Work type:Article
Typology:1.02 - Review Article
Organization:FFA - Faculty of Pharmacy
Publication status:Published
Publication version:Version of Record
Number of pages:28 str.
Numbering:Vol. 25, iss. 20, art. 4647
PID:20.500.12556/RUL-134403 This link opens in a new window
ISSN on article:1420-3049
DOI:10.3390/molecules25204647 This link opens in a new window
COBISS.SI-ID:32284931 This link opens in a new window
Publication date in RUL:13.01.2022
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Shortened title:Molecules
COBISS.SI-ID:18462981 This link opens in a new window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:12.10.2020

Secondary language

Keywords:kurkumin, hidroksicinamska kislina, prion protein, amiloidna transformacija, Parkinsonova bolezen, nevrodegenerativne bolezni


Funder:Drugi - Drug financer ali več financerjev
Funding programme:Russian Foundation for Basic Research
Project number:19-34-80004

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P1-0208
Name:Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:BI-RU/19-20-040

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