Natural sources, pharmacokinetics, biological activities and health benefits of hydroxycinnamic acids and their metabolites

Sova, Matej (author), Saso, Luciano (author)

Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations in fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged in food products rich in HCAs; however, food processing, dietary intake, bioaccessibility and pharmacokinetics have a high impact on HCAs to reach the target tissue in order to exert their biological activities. In particular, metabolism is of high importance since HCAs' metabolites could either lose the activity or be even more potent compared to the parent compounds. In this review, natural sources and pharmacokinetic properties of HCAs and their esters are presented and discussed. The main focus is on their metabolism along with biological activities and health benefits. Special emphasis is given on specific effects of HCAs' metabolites in comparison with their parent compounds.

• Language: English
• Keywords: diet, natural compounds, phenolic acids, hydroxycinnamic acids, metabolites, pharmacokinetic properties, biological activities, health effects
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 30 str.
• Numbering: Vol. 12, iss. 8, art. 2190
• PID: 20.500.12556/RUL-134381
• UDC: 577.121:613
• ISSN on article: 2072-6643
• DOI: 10.3390/nu12082190
• COBISS.SI-ID: 24845827
• Publication date in RUL: 12.01.2022

Record is a part of a journal

• Title: Nutrients
• Shortened title: Nutrients
• Publisher: MDPI
• ISSN: 2072-6643
• COBISS.SI-ID: 2948140

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.08.2020

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0208
• Name: Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin